Characterization and Outcomes in Patients Treated With Apremilast in Routine Clinical Practice in Spain: Results From the APPRECIATE Study
Por:
Herranz P, Trasobares L, Mateu A, Martínez E, Ruiz-Villaverde R, Baniandrés O, Mataix J, Jiménez-Gómez N, Serra M, Ruiz Genao DP, Rivera N, Tercedor-Sánchez J, Garcia C, Cordey M and Herrera-Acosta E
Publicada:
1 oct 2021
Ahead of Print:
1 oct 2021
Resumen:
Background and objectives: It is necessary to expand the knowledge in the use of apremilast in clinical practice. The APPRECIATE study (NCT02740218) aims to describe the characteristics of patients with psoriasis treated with apremilast, to evaluate their perspectives and those of dermatologists, as well as the outcomes obtained in clinical practice in Spain.
Methods: Observational, retrospective, cross-sectional, multicenter study of patients with chronic plaque psoriasis who could be contacted 6 (+/- 1) months after apremilast initiation. The data were obtained from medical records and questionnaires from patients and physicians.
Results: A total of 80 patients were evaluated; at apremilast onset, they showed mean (standard deviation, SD) Psoriasis Area and Severity Index (PASI) = 8.3 (5.3), mean (SD) Dermatology Life Quality Index (DLQI) = 8.9 (6.6). At six months, 58.8% (n=47) of patients continued apremilast treatment (discontinuations due to lack of efficacy [16.3%], safety/tolerability [20.0%]). In patients continuing treatment, PASI75 was achieved by 36.7% of patients; mean (95% CI) DLQI score was 2.2 (0.7-3.6) and mean (SD) Patient Benefit Index score was 2.8 (0.8). Compliance with physicians' expectations was correlated with benefits reported by patients (r=0.636). Adverse events were reported by 56.3% of patients (the most common were diarrhoea and nausea).
Conclusions: Patients receiving apremilast for 6 months in Spanish clinical practice, reported substantial improvements in their quality of life (mean DLQI reduced by more than 6 points) and disease severity (PASI75 achieved by over one-third of patients), despite less skin involvement than patients who enrolled in clinical trials. (C) 2021 AEDV. Published by Elsevier Espana, S.L.U.
Filiaciones:
Herranz P:
Hospital Universitario La Paz, Madrid, España
Trasobares L:
Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España
:
Hospital Universitario Doctor Peset, Valencia, España
:
Hospital Lluís Alcanyís Xàtiva, Valencia, España
Ruiz-Villaverde R:
Hospital Clínico Universitario San Cecilio, Granada, España
Baniandrés O:
Hospital General Universitario Gregorio Marañón, Madrid, España
:
Hospital Marina Baixa, Villajoyosa, Alicante, España
Jiménez-Gómez N:
Hospital Ramon y Cajal, Madrid, España
Serra M:
Hospital Can Misses, Illes Balears, España
Ruiz Genao DP:
Fundación Hospital Alcorcón, Alcorcón, Madrid, España
Rivera N:
Hospital de Mollet, Mollet del Vallès, Barcelona, España
Tercedor-Sánchez J:
Hospital Universitario Virgen de las Nieves, Granada, España
Garcia C:
Amgen Inc, Madrid, España
Cordey M:
Amgen Inc, Amgen (Europe) GmbH, Rotkreuz, Switzerland
Herrera-Acosta E:
Vithas Xanit Iinternational Hospital, Benalmádena, Málaga, España
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