Alzemon: a prospective follow-up study of eslicarbazepine acetate monotherapy in patients with newly diagnosed epilepsy
Por:
Hernandez L, Asensio-Asensio M, Tortosa-Conesa D, Alfaro-Sáez A, García-Escrivá A, Díaz-Román M, Montoya J, Méndez-Miralles MA, Bertol-Alegre V, Castro-Vilanova MD, Galiano ML, Blanco-Cantó ME and López-González F
Publicada:
15 abr 2021
Resumen:
Aim. To evaluate the effectiveness of eslicarbazepine as initial monotherapy in patients with newly diagnosed partial epilepsy in routine clinical practice.
Patients and methods. A prospective, multicentre, post-authorisation study. Patients with newly diagnosed partial epilepsy aged 18 years or older without previous treatment were included. The efficacy variables were: percentage of seizure-free patients, responders and reduction in monthly frequency of seizures. The safety variables analyse the 12-month retention rate and the occurrence of adverse effects.
Results. Fifty-three patients were included. The retention rate was 77.4%. At the end of the observation period, 83% of patients were seizure-free and 92.5% had reduced their baseline frequency by 50% or more. In addition, 68% of the patients reported some adverse effect and 7.5% of them dropped out of the study for this reason. The effectiveness analysis of the subgroup of patients aged 65 years or more showed no differences with respect to the overall population.
Conclusion. Eslicarbazepine monotherapy in patients with newly diagnosed partial epilepsy, both in the general population and in the population over 65 years old, is effective and safe in routine clinical practice.
Filiaciones:
Hernandez L:
Hospital General Universitario de Elda, 03600 Elda, España
Asensio-Asensio M:
Hospital General Universitario de Alicante, Alicante, España
Tortosa-Conesa D:
Hospital Universitario Virgen de la Arrixaca, El Palmar, España
:
Hospital Vega Baja, 03314 Orihuela, España
Universidad Miguel Hernández, Elche, España
:
Hospital Marina Salud, Denia, España
:
Hospital Lluís Alcanyís de Xàtiva, Xàtiva, España
Montoya J:
Hospital General Universitario de Valencia, Valencia, España
:
Hospital Universitario de Torrevieja, Torrevieja, España
Bertol-Alegre V:
HUMS. Hospital Universitario Miguel Servet, 50009 Zaragoza, España
Castro-Vilanova MD:
Complejo Hospitalario Universitario de Vigo, 36200 Vigo, España
Galiano ML:
Hospital Universitario Gregorio Marañón, Madrid, España
Blanco-Cantó ME:
Hospital Marina Salud, Denia, España
López-González F:
Hospital General Universitario de Alicante, Alicante, España
|