Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study
Por:
Hinchliffe A, Kogevinas M, Pérez-Gómez B, Ardanaz E, Amiano P, Marcos-Delgado A, Castaño-Vinyals G, Llorca J, Moreno V, Alguacil J, Fernandez-Tardón G, Salas D, Marcos-Gragera R, Aragonés N, Guevara M, Gil L, Martin V, Benavente Y, Gomez-Acebo I, Santibáñez M, Ángel Alba M, García AM, Pollán M and Turner MC
Publicada:
1 feb 2021
Ahead of Print:
2 dic 2020
Resumen:
Background: Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited.
Methods: We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed (P >= 25% for at least 1 year) and work time with heat stress (wet bulb globe temperature ISO 7243) for each occupation. We used three exposure indices: ever versus never exposed, lifetime cumulative exposure, and duration of exposure (years). We estimated ORs and 95% confidence intervals (CI), applying a lag period of 5 years and adjusting for potential confounders.
Results: Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46), with significant trends across categories of lifetime cumulative exposure and duration (P-trend = 0.01 and 0.03, respectively). Stronger associations were found for hormone receptor-positive disease (OR ever exposure = 1.38; 95% Cl, 1.12-1.67). We found no confounding effects from multiple other common occupational exposures; however, results attenuated with adjustment for occupational detergent exposure.
Conclusions: This study provides some evidence of an association between occupational heat exposure and female breast cancer risk.
Impact: Our results contribute substantially to the scientific literature. Further investigations are needed considering multiple occupational exposures.
Filiaciones:
Hinchliffe A:
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Kogevinas M:
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Pérez-Gómez B:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Ardanaz E:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Instituto de Salud Pública de Navarra (IdiSNA), Pamplona, Spain
Amiano P:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Ministry of Health of the Basque Government, San Sebastian, Spain
Marcos-Delgado A:
Instituto de Biomedicina (IBIOMED)
Castaño-Vinyals G:
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Llorca J:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
University of Cantabria - IDIVAL, Santander, Spain
Moreno V:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO) and Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Alguacil J:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain
Fernandez-Tardón G:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Institute of Health Research of the Principality of Asturias (ISPA), Public Health Department, University of Oviedo, Oviedo, Spain
:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Valencia, Spain
General Directorate Public Health, Valencian Community, Valencia, Spain
Marcos-Gragera R:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona, Spain
Descriptive Epidemiology, Genetics and Cancer Prevention Group, Biomedical Research Institute (IDIBGI), Girona, Spain
Aragonés N:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
Guevara M:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Instituto de Salud Pública de Navarra (IdiSNA), Pamplona, Spain
Gil L:
Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Ministry of Health of the Basque Government, San Sebastian, Spain
Martin V:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Instituto de Biomedicina (IBIOMED)
Benavente Y:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, IDIBELL, Institut Català d'Oncologia, L'Hospitalet De Llobregat, Barcelona, Spain
Gomez-Acebo I:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
University of Cantabria - IDIVAL, Santander, Spain
Santibáñez M:
University of Cantabria - IDIVAL, Santander, Spain
Ángel Alba M:
Industrial Hygiene Department, Quirón Prevención, S.L.U., Barcelona, Barcelona, Spain
:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Departamento de Medicina Preventiva y Salud Pública, Universitat de València, València, Spain
Center for Research in Occupational Health (CiSAL), Universitat Pompeu Fabra, Barcelona, Spain
Pollán M:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Turner MC:
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain
McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada
Bronze
|