Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study
Por:
Carrasco P, Estarlich M, Iñiguez C, Ferrero A, Murcia M, Esplugues A, Vioque J, Marina LS, Zabaleta C, Iriarte G, Fernández-Somoano A, Tardon A, Vrijheid M, Sunyer J, Ballester F and Llop S
Publicada:
15 ago 2021
Ahead of Print:
1 abr 2021
Resumen:
Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between pre and postnatal mercury exposure and respiratory and allergy problems among preschool children and to examine the role of potential modifying factors. Study subjects were children participant in Spanish Childhood and Environment Project (INMA, 2003-2008). We measured total mercury levels in cord blood (n = 1868) and hair at 4 years of age (n = 1347). Respiratory outcomes (wheezing, severe wheezing, chestiness, persistent cough, eczema and otitis) were obtained by questionnaires administered to parents. Associations were investigated by logistic regression adjusted for socio-demographic and lifestyle-related variables in each cohort and subsequent meta-analysis. We tested effect modification by factors related to individual susceptibility, diet and coexposure with other pollutants. The geometric mean of cord blood and hair total mercury was 8.20 mu g/L and 0.97 mu g/g, respectively. No statistically significant association between pre or postnatal mercury exposure and respiratory and allergy outcomes was found. Notwithstanding, lower maternal intake of fruits and vegetables increased the risk of some respiratory outcomes due to the prenatal exposure to mercury (p(int) < 0.05). Moreover, an inverse association between prenatal mercury exposure and some respiratory outcomes was observed among children with higher maternal exposure to organocholorine compounds or smoking (p(int) < 0.05). Also, sex and postnatal smoking exposure modulated mercury postnatal effects on persistent cough (p(int) < 0.05). In conclusion, no association between pre and postnatal mercury exposure and respiratory and allergy problems among the whole population at study was found. However, diet and other toxicants could modulate this relation, especially during prenatal period. More research on this topic is warranted due to the limited evidence. (C) 2021 Elsevier B.V. All rights reserved.
Filiaciones:
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Department of Medicine, Universitat Jaume I, Avenida de Vicent Sos Baynat s/n, 12071 Castellón de la Plana, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Nursing School, Universitat de València, C/Jaume Roig s/n, 46010, Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Department of Statistics and Computational Research. Universitat de València, València, Dr. Moliner, 50 46100, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Servicio de Análisis de Sistemas de Información Sanitaria, Conselleria de Sanitat, Generalitat Valenciana. C/Micer Mascó, 31-33, 46010, Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Nursing School, Universitat de València, C/Jaume Roig s/n, 46010, Valencia, Spain
Vioque J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Institute for Health and Biomedical Research (ISABIAL), Avda Pinto Baeza, 12, 03010 AlicanteAlicante, Spain
Marina LS:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Health Department of Basque Government, Sub-directorate of Public Health of Gipuzkoa, Avenida de Navarra 4, 20013 San Sebastián, Spain
Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Public Health Division of Gipuzkoa, Doctor Begiristain, s/n, 20014 San Sebastián, Spain
Zabaleta C:
Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Public Health Division of Gipuzkoa, Doctor Begiristain, s/n, 20014 San Sebastián, Spain
Nuestra señora de la Antigua Hospital, OSI Goierri-Alto Urola, OSAKIDETZA-Basque Health Service, Barrio Argixao, s/n, 20700 Zumarraga, Spain
Iriarte G:
Laboratorio de Salud Pública de Alava, Santiago 11, 01002 Vitoria Gasteiz, Spain
Fernández-Somoano A:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
IUOPA-Departamento de Medicina, University of Oviedo, Av. Julián Clavería, 6, 33006 Oviedo, Spain
Institute of Health Research of the Principality of Asturias - Foundation for Biosanitary Research of Asturias (ISPA-FINBA), Avenida Hospital Universitario s/n, 33011, Oviedo, Spain
Tardon A:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
IUOPA-Departamento de Medicina, University of Oviedo, Av. Julián Clavería, 6, 33006 Oviedo, Spain
Institute of Health Research of the Principality of Asturias - Foundation for Biosanitary Research of Asturias (ISPA-FINBA), Avenida Hospital Universitario s/n, 33011, Oviedo, Spain
Vrijheid M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Barcelona Institute for Global Health (ISGlobal), Dr. Aiguader 88, 08003 Barcelona, Spain
Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10-12, 08002 Barcelona, Spain
Sunyer J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Barcelona Institute for Global Health (ISGlobal), Dr. Aiguader 88, 08003 Barcelona, Spain
Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10-12, 08002 Barcelona, Spain
Municipal Institute of Medical Research, IMIM-Hospital del Mar, Dr. Aiguader 88, 08003 Barcelona, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Nursing School, Universitat de València, C/Jaume Roig s/n, 46010, Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Green Published, hybrid
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