Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly
Por:
Bernabeu, I, Fajardo, C, Marazuela, M, Cordido, F, Venegas, E, de Pablos-Velasco, P, Maroto, G, Olvera, M, de Paz, I, Carvalho, D, Romero, C, De la Cruz, G and Escola, C
Publicada:
1 dic 2020
Ahead of Print:
1 jul 2020
Resumen:
Purpose Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly injections of long-acting somatostatin analogues (SSAs). We further evaluated the effectiveness of lanreotide autogel 120 mg delivered at EDIs (>4 weeks) in routine clinical practice. Methods Cross-sectional, multicentre, observational study conducted to determine the effectiveness-measured by control of serum insulin-like growth factor 1 (IGF-1)-of lanreotide autogel 120 mg at dosing intervals >4 weeks for >= 6 months in selected patients with acromegaly treated in routine clinical practice (NCT02807233). Secondary assessments included control of growth hormone (GH) levels, treatment adherence, patient satisfaction, and quality of life (QoL) using validated questionnaires (EQ-5D, AcroQoL, and TSQM-9). Patients who received radiotherapy within the last 6 months were excluded. Results Among 109 patients evaluated, mean (SD) age was 59.1 (13.2) years. IGF-1 values were normal (mean [SD]: 175.0 [74.5], 95% CI: 160.8 -189.1) in 91.7% of cases and normal in 91.4% of patients without previous radiotherapy treatment (n = 81). GH levels were <= 2.5 and <= 1 ng/mL, respectively, in 80.6% and 58.3%. Most patients were treated either every 5-6 (57.8%) or 7-8 weeks (38.5%), with 2.8% treated greater than every 8 weeks. The mean AcroQoL score was 63.0 (20.1). The mean global treatment satisfaction score (TSQM-9) was 75.1 (16.6). Treatment adherence (defined as no missed injections) was 94.5%. Conclusion Lanreotide autogel 120 mg at intervals of >4 weeks provided IGF-1 control in more than 90% of patients with acromegaly. Treatment satisfaction and adherence were good. These findings support use of extended dosing intervals in patients who have achieved good biochemical control with long-acting SSAs.
Filiaciones:
Bernabeu, I:
Hosp Clin Univ Santiago de Compostela, Endocrinol & Nutr Dept, Santiago De Compostela, Spain
:
Hosp Univ La Ribera, Endocrinol & Nutr Dept, Alzira, Valencia, Spain
Marazuela, M:
Univ Autonoma Madrid, Hosp Univ La Princesa, Inst Princesa, Endocrinol & Nutr Dept, Madrid, Spain
Cordido, F:
Univ A Coruna, Fac Hlth Sci, La Coruna, Spain
Univ A Coruna, INIBIC, La Coruna, Spain
Complejo Hosp Univ A Corana, Endocrinol & Nutr Dept, La Coruna, Spain
Venegas, E:
Hosp Univ Virgen del Rocio, Endocrinol & Nutr Dept, Seville, Spain
de Pablos-Velasco, P:
Univ Las Palmas Gran Canaria, Endocrinol & Nutr Dept, Las Palmas Gran Canaria, Spain
Maroto, G:
Hosp Univ Virgen de las Nieves, Endocrinol & Nutr Dept, Granada, Spain
Olvera, M:
Hosp Univ Nuestra Senora Candelaria, Endocrinol & Nutr Dept, Santa Cruz De Tenerife, Spain
de Paz, I:
Hosp Univ Getafe, Endocrinol & Nutr Dept, Madrid, Spain
Carvalho, D:
Univ Porto, Ctr Hosp Univ Sao Joao, Fac Med, Dept Endocrinol Diabet & Metab,i3S, Porto, Portugal
Romero, C:
Adknoma Hlth Res SL, Barcelona, Spain
De la Cruz, G:
Ipsen Pharma, Barcelona, Spain
Escola, C:
Hosp Univ La Paz, Endocrinol & Nutr Dept, Madrid, Spain
Green Published, hybrid
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