Risk of gastric cancer in the environs of industrial facilities in the MCC- Spain study*
Por:
García-Pérez J, Lope V, Fernández de Larrea-Baz N, Molina AJ, Tardón A, Alguacil J, Pérez-Gómez B, Moreno V, Guevara M, Castaño-Vinyals G, Jiménez-Moleón JJ, Gómez-Acebo I, Molina-Barceló A, Martín V, Kogevinas M, Pollán M and Aragonés N
Publicada:
1 jun 2021
Ahead of Print:
1 mar 2021
Resumen:
Background: Gastric cancer is the fifth most frequent tumor worldwide. In Spain, it presents a large geographic variability in incidence, suggesting a possible role of environmental factors in its etiology. Therefore, epidemiologic research focused on environmental exposures is necessary.
Objectives: To assess the association between risk of gastric cancer (by histological type and tumor site) and residential proximity to industrial installations, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer conducted in Spain (MCC-Spain).
Methods: In this study, 2664 controls and 137 gastric cancer cases from 9 provinces, frequency matched by province of residence, age, and sex were included. Distances from the individuals' residences to the 106 industries located in the study areas were computed. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industries, adjusting for matching variables and potential confounders.
Results: Overall, no excess risk of gastric cancer was observed in people living close to the industrial installations, with ORs ranging from 0.73 (at <2.5 km) to 0.93 (at <1.5 km). However, by industrial sector, excess risks (OR; 95%CI) were found near organic chemical industry (3.51; 1.42-8.69 at <2 km), inorganic chemical industry (3.33; 1.12-9.85 at <2 km), food/beverage sector (2.48; 1.12-5.50 at <2 km), and surface treatment using organic solvents (3.59; 1.40-9.22 at <3 km). By specific pollutant, a statistically significant excess risk (OR; 95%CI) was found near (<3 km) industries releasing nonylphenol (6.43; 2.30-17.97) and antimony (4.82; 1.94-12.01).
Conclusions: The results suggest no association between risk of gastric cancer and living in the proximity to the industrial facilities as a whole. However, a few associations were detected near some industrial sectors and installations releasing specific pollutants.
(c) 2021 Elsevier Ltd. All rights reserved.
Filiaciones:
García-Pérez J:
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Lope V:
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Fernández de Larrea-Baz N:
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Molina AJ:
The Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de León, Campus Universitario de Vegazana, 24071, León, Spain
Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, Campus Universitario de Vegazana, 24071, León, Spain
Tardón A:
Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Facultad de Medicina, Campus de El Cristo B, 33006, Oviedo, Spain
Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Av. Roma S/n, 33011, Oviedo, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Alguacil J:
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente, Universidad de Huelva, Campus Universitario de El Carmen, 21071, Huelva, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Pérez-Gómez B:
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Moreno V:
Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Hospital Duran I Reynals, Avinguda de La Gran Via de L'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Avinguda de La Gran Via de L'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Carrer de Casanova 143, 08036, Barcelona, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Guevara M:
Navarra Public Health Institute, Calle Leyre, 15, 31003, Pamplona, Navarra, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Navarra Institute for Health Research (IdiSNA), Calle Leyre 15, 31003, Pamplona, Spain
Castaño-Vinyals G:
ISGlobal, Carrer del Dr. Aiguader 88, 08003, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Campus Del Mar, Carrer Del Dr. Aiguader 80, 08003, Barcelona, Spain
IMIM (Hospital Del Mar Medical Research Institute), Carrer Del Dr. Aiguader 80, 08003, Barcelona, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address:
Jiménez-Moleón JJ:
Department of Preventive Medicine and Public Health, School of Medicine, University of Granada, Av. de La Investigación 11, 18016, Granada, Spain
Instituto de Investigación Biosanitaria Ibs.GRANADA, Doctor Azpitarte 4 4(a) Planta, Edificio Licinio de La Fuente, 18012, Granada, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Gómez-Acebo I:
Universidad de Cantabria - IDIVAL, Avenida Cardenal Herrera Oria S/n, 39011, Santander, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
:
Cancer and Public Health Area, FISABIO - Public Health, Avda. de Catalunya 21, 46020, Valencia, Spain
Martín V:
The Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de León, Campus Universitario de Vegazana, 24071, León, Spain
Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, Campus Universitario de Vegazana, 24071, León, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Kogevinas M:
ISGlobal, Carrer del Dr. Aiguader 88, 08003, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Campus Del Mar, Carrer Del Dr. Aiguader 80, 08003, Barcelona, Spain
IMIM (Hospital Del Mar Medical Research Institute), Carrer Del Dr. Aiguader 80, 08003, Barcelona, Spain
Pollán M:
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
Aragonés N:
Epidemiology Section, Public Health Division, Department of Health of Madrid, C/San Martín de Porres, 6, 28035, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain
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