Quality of life and non-motor symptoms in Parkinson's disease patients with subthreshold depression
Por:
Santos-Garcia, D, Fonticoba, T, Castro, E, Diaz, A, Bartolome, C, Panceiras, M, Gonzalez, J, Aymerich, L, Moreno, J, Estrada, M, Jesus, S, Mir, P, Aguilar, M, Planellas, L, Caldentey, J, Caballol, N, Legarda, I, Lopez, I, Manzanares, L, Rivera, M, Catalan, M, Diaz, L, Borrue, C, Sauco, M, Vela, L, Cubo, E, Castrillo, J, Alonso, P, Losada, M, Ariztegui, N, Gaston, I, Pascual-Sedano, B, Seijo, M, Martinez, J, Valero, C, Kurtis, M, Ardura, J, Jurczynska, C and Martinez-Martin, P
Publicada:
15 nov 2020
Resumen:
Background: The role of subthreshold depression (subD) in Parkinson's Disease (PD) is not clear. The present study aimed to compare the quality of life (QoL) in PD patients with subD vs patients with no depressive disorder (nonD). Factors related to subD were identified.
Material and methods: PD patients and controls recruited from the COPPADIS cohort were included. SubD was defined as Judd criteria. The 39-item Parkinson's disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8) were used to assess QoL.
Results: The frequency of depressive symptoms was higher in PD patients (n = 694) than in controls (n = 207) (p < 0.0001): major depression, 16.1% vs 7.8%; minor depression, 16.7% vs 7.3%; subD, 17.4% vs 5.8%. Both health-related QoL (PDQ-39; 18.1 +/- 12.8 vs 11.6 +/- 10; p < 0.0001) and global QoL (EUROHIS-QOL8; 3.7 +/- 0.5 vs 4 +/- 0.5; p < 0.0001) were significantly worse in subD (n = 120) than nonD (n = 348) PD patients. Non-motor Symptoms Scale (NMSS) total score was higher in subD patients (45.9 +/- 32 vs 29.1 +/- 25.8;p < 0.0001). Non-motor symptoms burden (NMSS;OR = 1.019;95%CI 1.011-1.028; p < 0.0001), neuropsychiatric symptoms (NPI; OR = 1.091; 95%CI 1.045-1.139; p < 0.0001), impulse control behaviors (QUIP-RS; OR = 1.035; 95%CI 1.007-1063; p = 0.013), quality of sleep (PDSS; OR = 0.991; 95%CI 0.983-0.999; p = 0.042), and fatigue (VAFS-physical; OR = 1.185; 95%CI 1.086-1.293; p < 0.0001; VAFS-mental; OR = 1.164; 95%CI 1.058-1.280; p = 0.0001) were related to subD after adjustment to age, disease duration, daily equivalent levodopa dose, motor status (UPDRS-III), and living alone.
Conclusions: SubD is a frequent problem in patients with PD and is more prevalent in these patients than in controls. QoL is worse and non-motor symptoms burden is greater in subD PD patients.
Filiaciones:
Santos-Garcia, D:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Fonticoba, T:
Complejo Hosp Univ Ferrol CHUF, Hosp Arquitecto Marcide, Ferrol, A Coruna, Spain
Complejo Hosp Univ Ferrol CHUF, Hosp Naval, Ferrol, A Coruna, Spain
Castro, E:
Complejo Hosp Univ Ferrol CHUF, Hosp Arquitecto Marcide, Ferrol, A Coruna, Spain
Complejo Hosp Univ Ferrol CHUF, Hosp Naval, Ferrol, A Coruna, Spain
Diaz, A:
Complejo Hosp Univ Ferrol CHUF, Hosp Arquitecto Marcide, Ferrol, A Coruna, Spain
Complejo Hosp Univ Ferrol CHUF, Hosp Naval, Ferrol, A Coruna, Spain
Bartolome, C:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Panceiras, M:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Gonzalez, J:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Aymerich, L:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Moreno, J:
Hosp Univ Virgen Macarena, Seville, Spain
Estrada, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Jesus, S:
Hosp Univ Virgen del Rocio, Seville, Spain
Mir, P:
Hosp Univ Virgen del Rocio, Seville, Spain
Aguilar, M:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Planellas, L:
Hosp Clin Barcelona, Barcelona, Spain
Caldentey, J:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Lopez, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Manzanares, L:
Hosp La Princesa, Madrid, Spain
Rivera, M:
Hosp Gen Hospitalet, Consorci Sanitari Integral, Barcelona, Spain
Catalan, M:
Hosp Univ Clin San Carlos, Madrid, Spain
Diaz, L:
Complejo Hosp Univ Ourense CHUO, Orense, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Castrillo, J:
Hosp Univ Ramon Y Cajal, Madrid, Spain
Alonso, P:
Hosp Univ Puerta de Hierro, Madrid, Spain
Losada, M:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Ariztegui, N:
Complejo Hosp Toledo, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona, Spain
Pascual-Sedano, B:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Seijo, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Martinez, J:
Hosp Univ Donostia, San Sebastian, Spain
:
Hosp Arnau Vilanova, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
Ardura, J:
Hosp Univ Lucus Augusti HULA, Lugo, Spain
Jurczynska, C:
Hosp Rey Juan Carlos, Madrid, Spain
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Inst Salud Carlos III, CIBERNED, COPPADIS Study Grp, Madrid, Spain
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