Mood in Parkinson's disease: From early- to late-stage disease


Por: Santos-Garcia, D, De Deus, F, Cores, B, Valdes, A, Suarez, C, Aneiros, A, Jesus, S, Aguilar, M, Pastor, P, Planellas, L, Cosgaya, M, Garcia, C, Caballol, N, Legarda, I, Hernandez, V, Cabo, I, Lopez, M, Gonzalez, A, Avila, R, Jose, C, Nogueira, V, Puente, V, Garcia, M, Borrue, C, Solano, V, Alvarez, S, Vela, L, Escalante, S, Cubo, E, Carrillo, P, Martinez, C, Sanchez, A, Alonso, L, Lopez, A, Gaston, I, Kulisevsky, J, Blazquez, E, Seijo, M, Ruiz, M, Valero, C, Kurtis, M, de Fabregues-Boixar, O, Gonzalez, A, Prieto, J, Lopez, D, McAfee, D, Mir, P and COPPADIS Study Grp

Publicada: 1 may 2021 Ahead of Print: 1 nov 2020
Resumen:
Background Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: <5 years (Group A); from 5 to <10 years (Group B); >= 10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable). Results Six hundred and sixty-three PD patients (62.6 +/- 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.

Filiaciones:
Santos-Garcia, D:
 Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain

De Deus, F:
 Complejo Hosp Univ Ferrol CHUF, La Coruna, Spain

Cores, B:
 Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain

Valdes, A:
 Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain

Suarez, C:
 Complejo Hosp Univ Ferrol CHUF, La Coruna, Spain

Aneiros, A:
 Complejo Hosp Univ Ferrol CHUF, La Coruna, Spain

Jesus, S:
 Hosp Univ Virgen Rocio, Seville, Spain

 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

Aguilar, M:
 Hosp Univ Mutua Terrassa, Barcelona, Spain

Pastor, P:
 Hosp Univ Mutua Terrassa, Barcelona, Spain

Planellas, L:
 Hosp Clin Barcelona, Barcelona, Spain

Cosgaya, M:
 Hosp Clin Barcelona, Barcelona, Spain

Garcia, C:
 Ctr Neurol Oms 42, Palma de Mallorca, Spain

Caballol, N:
 Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain

Legarda, I:
 Hosp Univ Son Espases, Palma De Mallorca, Spain

Hernandez, V:
 Hosp Univ Vall dHebron, Barcelona, Spain

Cabo, I:
 Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain

Lopez, M:
 Hosp Univ La Princesa, Madrid, Spain

Gonzalez, A:
 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

 Hosp Univ Marques Valdecilla, Santander, Spain

Avila, R:
 Hosp Gen LHospitalet, Consorci Sanitari Integral, Barcelona, Spain

Jose, C:
 Hosp Univ Clin San Carlos, Madrid, Spain

Nogueira, V:
 Hosp Da Costa, Lugo, Spain

Puente, V:
 Hosp del Mar, Barcelona, Spain

Garcia, M:
 Hosp Univ Virgen Macarena, Seville, Spain

Borrue, C:
 Hosp Infanta Sofia, Madrid, Spain

Solano, V:
 Inst Catala Salut, Inst Assistencia Sanitaria IAS, Girona, Spain

:
 Hosp Gen Univ Elche, Elche, Spain

Vela, L:
 Fdn Hosp Alcorcon, Madrid, Spain

Escalante, S:
 Hosp Tortosa Verge Cinta HTVC, Tarragona, Spain

Cubo, E:
 Complejo Asistencial Univ Burgos, Burgos, Spain

Carrillo, P:
 Hosp Univ Canarias, San Cristobal De La Lagu, Santa Cruz De T, Spain

Martinez, C:
 Hosp Univ Ramon Y Cajal, Madrid, Spain

Sanchez, A:
 Hosp Univ Puerta Hierro, Madrid, Spain

Alonso, L:
 Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain

Lopez, A:
 Complejo Hosp Toledo, Toledo, Spain

Gaston, I:
 Complejo Hosp Navarra, Pamplona, Spain

Kulisevsky, J:
 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

 Hosp Sant Pau, Barcelona, Spain

Blazquez, E:
 Hosp Univ Cent Asturias, Oviedo, Spain

Seijo, M:
 Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain

Ruiz, M:
 Hosp Univ Donostia, San Sebastian, Spain

:
 Hosp Arnau Vilanova, Valencia, Spain

Kurtis, M:
 Hosp Ruber Int, Madrid, Spain

de Fabregues-Boixar, O:
 Hosp Univ Vall dHebron, Barcelona, Spain

Gonzalez, A:
 Hosp Univ Lucus Augusti HULA, Lugo, Spain

Prieto, J:
 Hosp Rey Juan Carlos, Madrid, Spain

Lopez, D:
 Complejo Hosp Univ Orense CHUO, Orense, Spain

McAfee, D:
 Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

Mir, P:
 Hosp Univ Virgen Rocio, Seville, Spain

 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
ISSN: 08856230





INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
Editorial
WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, Reino Unido
Tipo de documento: Article
Volumen: 36 Número: 5
Páginas: 627-646
WOS Id: 000590684200001
ID de PubMed: 33169885

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