The Role of Autophagy in Eye Diseases
Por:
Fernández-Albarral JA, de Julián-López E, Soler-Domínguez C, de Hoz R, López-Cuenca I, Salobrar-García E, Ramírez JM, Pinazo-Durán MD, Salazar JJ and Ramírez AI
Publicada:
1 mar 2021
Ahead of Print:
27 feb 2021
Resumen:
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.
Filiaciones:
Fernández-Albarral JA:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
de Julián-López E:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
Soler-Domínguez C:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
de Hoz R:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
OFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, Spain
Departamento de Inmunología, Facultad de Óptica y Optometría, Oftalmología y ORL, UCM, 28037 Madrid, Spain
López-Cuenca I:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
Salobrar-García E:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
OFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, Spain
Departamento de Inmunología, Facultad de Óptica y Optometría, Oftalmología y ORL, UCM, 28037 Madrid, Spain
Ramírez JM:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
OFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, Spain
Departamento de Inmunología, Facultad de Medicina, Oftalmología y ORL, UCM, 28040 Madrid, Spain
:
OFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, Spain
Ophthalmic Research Unit "Santiago Grisolía"-FISABIO and Cellular and Molecular Ophthalmobiology Unit, University of Valencia, 46017 Valencia, Spain
Salazar JJ:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
OFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, Spain
Departamento de Inmunología, Facultad de Óptica y Optometría, Oftalmología y ORL, UCM, 28037 Madrid, Spain
Ramírez AI:
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
OFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, Spain
Departamento de Inmunología, Facultad de Óptica y Optometría, Oftalmología y ORL, UCM, 28037 Madrid, Spain
Green Accepted, gold, Green Published
|