The intestinal mycobiota and its relationship with overweight, obesity and nutritional aspects
Por:
García-Gamboa R, Kirchmayr MR, Gradilla-Hernández MS, Pérez-Brocal V, Moya A and González-Avila M
Publicada:
1 ago 2021
Ahead of Print:
1 feb 2021
Resumen:
Background The fungal community of the gastrointestinal tract has recently become of interest, and knowledge of its relationship with the development of obesity is scarce. The present study aimed to evaluate the cultivable fungal fraction from the microbiota and to analyze its relationship with obesity.
Methods Samples were taken from 99 participants with normal weight, overweight and obesity (n = 31, 34 and 34, respectively) and were cultivated in selective medium, and the cultivable yeasts were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anthropometric and biochemical measures were also evaluated.
Results Eutrophic, overweight and obese groups presented concentrations of 1.6, 2.16 and 2.19 log(10) colony-forming units g(-1) yeast, respectively. Ascomycota and Basidiomycota were the two identified phyla. At the genus level, Candida spp. showed a relatively high prevalence, and 10 different species were detected: Candida glabrata, Candida orthopsilosis, Candida lambica, Candida kefyr, Candida albicans, Candida krusei, Candida valida, Candida parapsilosis, Candida utilis and Candida humilis (with relative abundances of 71.72%, 5.05%, 21.21%, 6.06%, 29.29%, 27.27%, 8.08%, 16.16%, 1.01% and 2.02%, respectively).
Conclusions The obese group presented a higher prevalence of Candida albicans. Furthermore, Candida albicans, Candida kefyr and Rhodotorula mucilaginosa showed a high positive correlation with obesity, weight gain and fat mass and showed a negative correlation with high-density lipoprotein and lean mass, parameters related to weight loss.
Filiaciones:
García-Gamboa R:
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Guadalajara, Mexico
Kirchmayr MR:
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Guadalajara, Mexico
Gradilla-Hernández MS:
Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Zapopan, Jalisco, México
:
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp), Madrid, Spain
:
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp), Madrid, Spain
Integrative Systems Biology Institute (I2SysBio) Universitat de València and Consejo Superior de Investigaciones Científicas (CSIC), València, Spain
González-Avila M:
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Guadalajara, Mexico
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