Safety of nivolumab in metastatic renal cell carcinoma patients: A real-life experience in a Spanish urology setting
Por:
Bermudez, J, Garcia, I, Urzaiz, M, Marrero, P, Cepero, M, Llarena, R, Martin, J, Vivas-Perez, J, Aliaga, M and Soto, A
Publicada:
1 sep 2019
Categoría:
Urology
Resumen:
Introduction and objectives: Nivolumab is an immunotherapy agent that has been an approved treatment for previously treated patients with advanced renal cell carcinoma (RCC). Experience in real-life settings, especially regarding immune-related adverse events, is scarce. We present our experience with reference to the safety of nivolumab in patients with metastatic RCC (mRCC) treated in 9 hospitals in Spain.
Material and methods: Retrospective, multicentre study of patients with mRCC treated with nivolumab between 2016 and 2018. Data on baseline socio-demographic and clinical characteristics and drug-related adverse events were collected.
Results: The mean age of the 26 patients included was 63.7 11.5 years; 96% were ECOG 0-1 and 78% had favourable or intermediate MSKCC risk scores; 73% had the clear cell histological subtype and 30% metastatic disease. Median follow-up was 9 months (range 1-14). All patients experienced an adverse event at different grades, with fatigue, fever and anaemia being the most common (27%). Grade 3 adverse events occurred in 23% of patients. Adverse reactions led to treatment suspension in 3 patients (11%).
Conclusion: In the real-life clinical setting, nivolumab shows favourable outcomes, similar to those reported by other studies. (C) 2019 AEU. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Bermudez, J:
Hosp Univ Jerez, Serv Urol, Jerez de la Frontera, Spain
Garcia, I:
Hosp Virgen del Rocio, Serv Urol, Seville, Spain
Urzaiz, M:
Hosp Univ Basurto, Serv Urol, Bilbao, Spain
Marrero, P:
Hosp Univ Dr Negrin, Serv Urol, Las Palmas Gran Canaria, Spain
Cepero, M:
Hosp Univ Puerta del Mar, Serv Urol, Cadiz, Spain
Llarena, R:
Hosp Cruces, Serv Urol, Baracaldo, Spain
Martin, J:
Complejo Hosp Jaen, Serv Urol, Jaen, Spain
Vivas-Perez, J:
Hosp Poniente, Serv Urol, El Ejido, Almeria, Spain
:
Hosp Gen Univ Castellon, Serv Urol, Castellon de La Plana, Spain
Soto, A:
Hosp Univ Jerez, Serv Urol, Jerez de la Frontera, Spain
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