Sex differences in hospitalized adult patients with cellulitis: A prospective, multicenter study
Por:
Collazos J, de la Fuente B, de la Fuente J, García A, Gómez H, Rivas-Carmenado M, Suárez-Zarracina T, García-Carús E, Suárez S, Enríquez H, Sánchez P, Alonso M, López-Cruz I, Martín-Regidor M, Martínez-Alonso A, Guerra J, Artero A, Blanes M and Asensi V
Publicada:
1 mar 2021
Ahead of Print:
1 feb 2021
Resumen:
Objectives: Sex differences in adult cellulitis, a frequent cause of hospitalization, have not been analyzed. These differences were investigated in a large cellulitis series. Methods: This was a prospective observational study of 606 Spanish hospitalized cellulitis patients. Different comorbidities, clinical, diagnostic, and treatment data were compared between the sexes. Multiple logistic regression modeling was performed to determine the variables independently associated with sex. Results: Overall 606 adult cellulitis patients were enrolled; 314 (51. 8%) were male and 292 (48.2%) were female. Females were older (mean age 68.8 vs 58.9 years, p < 0.0001), less likely to have prior wounds (p = 0.02), and more likely to have venous insufficiency (p = 0.0002) and edema/lymphedema (p = 0.0003) than males. The location of the infection differed between the sexes (p = 0.02). Males were more likely to have positive pus cultures (p = 0.0008), the causing agent identified (p = 0.04), and higher rates of Staphylococcus aureus infection (p = 0.04) and received longer antibiotic treatment (p = 0.03). Factors independently associated with female sex in the multivariate analysis were older age (p < 0.0001), prior cellulitis (p = 0.01), presence of edema/lymphedema as the predisposing factor (p = 0.004), negative versus positive pus culture (p = 0.0002), and location of cellulitis other than in the lower extremities (p = 0.035). Conclusions: Differences between male and female patients with cellulitis were age, recurrence, presence of edema/lymphedema, positivity of pus culture, and topography of the infection. ? 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Filiaciones:
Collazos J:
Infectious Diseases Unit, Hospital de Galdácano, Vizcaya, Spain
de la Fuente B:
Infectious Diseases Unit, Hospital de Cabueñes, Gijón, Spain
de la Fuente J:
Internal Medicine Service, Hospital de Povisa, Vigo, Spain
García A:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Gómez H:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Rivas-Carmenado M:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Suárez-Zarracina T:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
García-Carús E:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Suárez S:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Enríquez H:
Internal Medicine Service, Hospital de Povisa, Vigo, Spain
Sánchez P:
Internal Medicine Service, Hospital de Povisa, Vigo, Spain
Alonso M:
Internal Medicine Service, Hospital de Povisa, Vigo, Spain
:
Internal Medicine Service, Hospital Dr Peset, Valencia, Spain
Martín-Regidor M:
Internal Medicine Service Complejo Hospitalario de León, Spain
Martínez-Alonso A:
Internal Medicine Service Complejo Hospitalario de León, Spain
Guerra J:
Internal Medicine Service Complejo Hospitalario de León, Spain
:
Internal Medicine Service, Hospital Dr Peset, Valencia, Spain
Blanes M:
Infectious Diseases Unit, Hospital La Fe, Valencia, Spain
Asensi V:
Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
Group of Translational Research in Infectious Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
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