Sex-differential effect of frailty on long-termmortality in elderly patients after an acute coronary syndrome
Por:
Núñez J, Palau P, Sastre C, D'Ascoli G, Ruiz V, Bonanad C, Miñana G, Núñez E and Sanchis J
Publicada:
1 mar 2020
Ahead of Print:
31 dic 2019
Categoría:
Cardiology and cardiovascular medicine
Resumen:
Background: The potential sex-differential effect of frailty in patients with acute coronary syndromes (ACS) has not been well-evaluated. We sought to examine the sex-differential association between frailty status on long-term mortality in elderly patients with an ACS.
Methods and results: This is a prospective observational single-center study that included 488 elderly patients (>65 years) hospitalized for ACS who survived the index hospitalization. Multivariate Cox regression was used to determine the association among the exposures (interaction of sex with Fried score and sex with Fried >= 3) and all-cause mortality. The mean age of the sample was 78 +/- 7 years; 41% were female and the median Fried score was higher in women [3 (2-3) vs. 2 (1-2) points, p < 0.001]. At a median follow-up of 3.12 years (IQR:1.38-5.13), 182 deaths (37.3%) were registered. The association of Fried >= 3 with mortality varied across sex (p-value for interaction = 0.022). In males, Fried >= 3 was independently associated with all-cause death (HR = 1.89; CI 95%:1.25-2.85, p = 0.003). However, it showed a neutral effect on women (HR = 0.92; CI 95%:0.57-1.49, p = 0.726).
Conclusions: In this work, we found that the frailty status assessed by Fried score was independently associated with mortality in elderly males but not in females with ACS. (C) 2019 Elsevier B.V. All rights reserved.
Filiaciones:
Núñez J:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
CIBER Cardiovascular
:
Servicio de Cardiología, Hospital General Universitario de Castellón, Universitat Jaume I, Castellón, Spain
Sastre C:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
CIBER Cardiovascular
D'Ascoli G:
Division of Cardiology, University of Rome Tor Vergata, Italy
Ruiz V:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
Bonanad C:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
Miñana G:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
Núñez E:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
Sanchis J:
Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain
CIBER Cardiovascular
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