The Role of Plasma Calprotectin in Non-infectious Uveitis
Por:
Pascual EV, Martínez-Costa Pérez L, Hernández Pons A, López Ortega JM, Grau García E, Albert Fort M, Alegre Sancho JJ and Ivorra JAR
Publicada:
3 ago 2021
Ahead of Print:
1 ene 2021
Resumen:
Purpose: To investigate the role of plasma calprotectin in non-infectious uveitis.
Methods: This is an observational both cross-sectional and prospective study. Patients with active non-infectious uveitis were recruited as well as nonuveitic controls. Plasma calprotectin was determined and an ophthalmological examination was performed for both patients and controls. Independent variables possibly influencing levels of plasma calprotectin were recorded and analyzed. Categorical variables were compared by chi-square test (applying correction by continuity if necessary). T-test (or Kruskal-Wallis when appropriate) was used to compare averages. Multiple linear regression analysis was used to assess relationship between plasma calprotectin levels and independent variables. Spearman coefficient was calculated in order to establish correlation between plasma calprotectin and anterior chamber cell grading. Changes in plasma calprotectin levels between the flare beginning and its resolution were determined with mixed model for repeated measures. R software (version 3.6.0) was used to perform the statistical analysis.
Results: We included 74 patients and 40 controls in the cross-sectional study. Plasma calprotectin levels were higher in uveitis patients compared to those of controls (p = .003), being higher in younger patients and patients with posterior uveitis. No correlation between calprotectin and anterior chamber inflammation degree was found (p = .198). For the prospective study, we included 36 patients. We found no significant differences in calprotectin levels between active and inactive uveitis (p = .344).
Conclusions: Plasma calprotectin levels are elevated in uveitis patients and are influenced by age and anatomical location of uveitis. Further investigation is needed to assess the relationship between calprotectin and uveitis activity.
Filiaciones:
:
Hospital Universitari Doctor Peset , Department of Rheumatology. Valencia (Spain)
Universidad Católica de Valencia San Vicente Mártir , Escuela de Doctorado. Valencia (Spain)
:
Hospital Universitari Doctor Peset , Department of Ophthalmology. Valencia (Spain)
:
Hospital Universitari Doctor Peset , Department of Ophthalmology. Valencia (Spain)
:
Hospital Universitari Doctor Peset , Department of Clinical Analysis. Valencia (Spain)
Grau García E:
Hospital Universitari I Politècnic La Fe , Department of Rheumatology. Valencia (Spain)
:
Hospital Universitari Doctor Peset , Department of Ophthalmology. Valencia (Spain)
:
Hospital Universitari Doctor Peset , Department of Rheumatology. Valencia (Spain)
Ivorra JAR:
Hospital Universitari I Politècnic La Fe , Department of Rheumatology. Valencia (Spain)
Universidad Catolica de Valencia San Vicente Martir Facultad de Medicina y Odontologia
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