Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: The LipoLab Study
Por:
Pallarés-Carratalá V, Quesada JA, Orozco D, Amigó-Grau N, Lopez-Pineda A, Fernández Giménez A, Gil V, Correig X, Masana L, Monleón D, Redón J, Pascual R and Carratalá-Munuera C
Publicada:
1 ene 2021
Ahead of Print:
1 nov 2020
Categoría:
Medicine (miscellaneous)
Resumen:
Background and aim Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of LDL-C and HDL-C, but with alterations in the number and size of lipoprotein particles (as measured by nuclear magnetic resonance [NMR]) and to analyse their sociodemographic, clinical and biochemical characteristics.
Methods Cross-sectional study in occupational risks prevention centre in Castellon (Spain) in 2017 and 2018, in consecutively recruited adults (18-65 years) with no known CVD. Sociodemographic, clinical and biochemical variables were collected. Lipid profiles were analysed (Liposcale test), along with the concentration, size and number of the main types of lipoprotein particles, determined by 2D diffusion-ordered NMR spectroscopy. Using contingency tables, we analysed the characteristics of people with normal LDL and HDL cholesterol but abnormal levels of LDL and HDL particles. The magnitude of association between explanatory variables and abnormal levels of each kind of lipoprotein was assessed with multivariable logistic regression models.
Results Of the 400 total participants (31.3% women; age 46.4 +/- 4.3 years), 169 had normal LDL and HDL cholesterol. Abnormal lipoprotein particle values depended on the subtype: prevalence of abnormal LDL levels ranged from 8.3% to 36.7%; and of HDL, from 28.4% to 42.6%. High systolic blood pressure and total cholesterol were significantly associated with abnormal LDL levels. Male sex and high systolic blood pressure were associated with abnormalities in HDL.
Conclusions An extended lipids profile, obtained by NMR, enables the identification of people with normal HDL-C and LDL-C levels who present abnormal levels of LDL-P and/or HDL-P. Higher total cholesterol, systolic blood pressure, BMI and male sex were significantly associated with these abnormal values.
Filiaciones:
Pallarés-Carratalá V:
Health Surveillance Unit, Castellón Mutual Insurance Union, Castellon, Spain
Department of Medicine, Jaume I University, Castellón, Spain
:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain
Orozco D:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain
Amigó-Grau N:
Biosfer Teslab, Reus, SL, Spain
CIBER of Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain
Fernández Giménez A:
Database Specialist, Exilio SI SL, Valencia, Spain
Gil V:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain
Research Unit General University Hospital of Elda, Elda, Spain
Correig X:
CIBER of Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
Metabolomics Platform, Universitat Rovira i Virgili, IISPV, Reus-Tarragona, Spain
Masana L:
CIBER of Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
Unit of research in lipids and arteriosclerosis (URLA), Hospital Universitari Sant Joan de Reus, Reus, Spain
Monleón D:
Department of Pathology, Universidad de Valencia, Spain
INCLIVA Research Institute, University of Valencia, Valencia, Spain
Redón J:
INCLIVA Research Institute, University of Valencia, Valencia, Spain
:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain
:
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain
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