Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke
Por:
Seijo-Bestilleiro, R, Seoane-Pillado, T, Pertega-Diaz, S, Gonzalez-Martin, C, Valdes-Canedo, F, Balboa-Barreiro, V, Fernandez-Rivera, C, Alonso-Hernandez, A, Cao-Vilarino, M, Gil V and Garcia-Rodriguez, M
Publicada:
1 ene 2020
Categoría:
Medicine (miscellaneous)
Resumen:
Background: measure the efficacy of exhaled carbon monoxide (CO) measurement plus brief advisory sessions to reduce smoking exposure and smoking behaviour in kidney transplant recipients.
Methods: Randomized, controlled, open-label clinical trial at a Spanish hospital. Smoking kidney transplant recipients giving their consent to participate were randomized to control (brief advice, n=63) or intervention group (brief advisory session plus measuring exhaled CO, n=59).
Measurements: Sociodemographic characteristics, cardiovascular risk factors, treatment, rejection episodes, infections, self-reported smoking, drug use, level of dependence and motivation to stop smoking (Fagerstrom's and Richmond's test) and stage of change (Prochaska and DiClemente's Stages). Efficacy was assessed at 3, 6, 9 and 12 months as: cotinine test, CO levels in exhaled air, nicotine dependence, motivational stages of change, motivation to stop smoking, pattern of tobacco use and smoking cessation rates.
Logistic regression models were computed.
Results: At 12 months of follow-up, differences were found in exhaled CO between the intervention and control group(6.1 +/- 6.8vs.10.2 +/- 9.7ppm;p=0.028). Carboxyhemoglobin levels were lower in the intervention group as well as the positive cotinine test (1.2 +/- 1.2%vs.2.0 +/- 2.4%;p=0.039),(53.4%vs.74.2%). At 12 months, intervention reduces the probability of a positive urine test by 28%.
Conclusions: Co-oximetry is a clinically relevant intervention for reduction of tobacco exposure in kidney transplant recipients.
Filiaciones:
Seijo-Bestilleiro, R:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Clin Epidemiol & Biostat Unit, La Coruna, Spain
Seoane-Pillado, T:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Clin Epidemiol & Biostat Unit, La Coruna, Spain
Pertega-Diaz, S:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Clin Epidemiol & Biostat Unit, La Coruna, Spain
Gonzalez-Martin, C:
Univ Coruna UDC, Complexo Hosp Univ A Coruna CHUAC, Invest Enfermeria & Cuidados Salud, Grp Invest Reumatol & Salud Publ,SERGAS, As Xubias 84, La Coruna 15006, Spain
Valdes-Canedo, F:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Nephrol Dept, La Coruna, Spain
Balboa-Barreiro, V:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Clin Epidemiol & Biostat Unit, La Coruna, Spain
Fernandez-Rivera, C:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Nephrol Dept, La Coruna, Spain
Alonso-Hernandez, A:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Nephrol Dept, La Coruna, Spain
Cao-Vilarino, M:
Univ A Coruna, Complexo Hosp Univ A Coruna CHUAC, Inst Invest Biomed A Coruna INIBIC, SERGAS,Nephrol Dept, La Coruna, Spain
Gil V:
Univ Miguel Hernandez San Juan Alicante, Dept Clin Med, Alicante, Spain
Garcia-Rodriguez, M:
Univ Coruna UDC, Complexo Hosp Univ A Coruna CHUAC, Invest Enfermeria & Cuidados Salud, Grp Invest Reumatol & Salud Publ,SERGAS, As Xubias 84, La Coruna 15006, Spain
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