Adverse Events Leading to Discontinuation of Phototherapy: An Observational Study
Por:
Belinchon, I, Sanchez-Pujol, M, Docampo, A, Cuesta, L, Schneller-Pavelescu, L and Ramos J
Publicada:
1 mar 2020
Resumen:
The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrowband UVB (NBUVB); 9.6% systemic psoralen plus UVA (PUVA); 11.4% topical PUVA; and 2.1% UVA. Approximately a fifth of the treatments (n= 240, 19.1%) were associated with AEs, the most frequent of which was erythema (8.8%). Systemic PUVA had the highest rate of AEs (32.5%). Mycosis fungoides was the dermatosis with the highest rate of AE (36.9%). A total of 216 (17.2%) patients stopped treatment: 23.6% because of AEs (4.1% of all treatments). Treatment suspension due to AEs was associated with PUVA, both topical and systemic (p < 0.001), and diagnoses of mycosis fungoides (p < 0.001), palmoplantar psoriasis (p = 0.002), hand eczema (p = 0.002) and pityriasis lichenoides (p = 0.01). In conclusion, one in every 5 patients receiving phototherapy had an AE, but few stopped treatment for this reason.
Filiaciones:
Belinchon, I:
Gen Univ Hosp Alicante ISABIAL, Serv Dermatol, Alicante, Spain
Univ Miguel Hernandez Elche, Dept Clin Med, Alicante, Spain
Sanchez-Pujol, M:
Gen Univ Hosp Alicante ISABIAL, Serv Dermatol, Alicante, Spain
Docampo, A:
Gen Univ Hosp Alicante ISABIAL, Serv Dermatol, Alicante, Spain
:
Univ Hosp San Juan, Serv Dermatol, Alicante, Spain
Schneller-Pavelescu, L:
Gen Univ Hosp Alicante ISABIAL, Serv Dermatol, Alicante, Spain
Ramos J:
Univ Miguel Hernandez Elche, Dept Clin Med, Alicante, Spain
gold, Green Published
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