Hipercolesterolemia familiar homocigota: adaptación a España del documento de posición del grupo de consenso sobre hipercolesterolemia familiar de la Sociedad Europea de Arteriosclerosis. Documento de Consenso de la Sociedad Española de Arteriosclerosis (SEA) y la Fundación Hipercolesterolemia Familiar (FHF).
Por:
Ascaso, J, Mata, P, Arbona, C, Civeira, F, Valdivielso, P and Masana, L
Publicada:
1 mar 2015
Ahead of Print:
8 mar 2015
Resumen:
Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening disease characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). The Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society (EAS) has recently published a clinical guide to diagnose and manage HoFH (Eur Heart J. 2014;35:2146-57). Both the Spanish Society of Atherosclerosis (SEA) and Familial Hypercholesterolaemia Foundation (FHF) consider this European Consensus document of great value and utility. However, there are particularities in our country which advise to have a Spanish adaptation of the European HoFH document in order to approximate this clinical guide to our environment. In Spain, chronic treatment with statins, ezetimibe and resins (colesevelam) has a reduced contribution in the National Health System (NHS) and is one of the few European countries where LDL apheresis is included in the Basic Service Portfolio coverage. This Spanish document also includes clinical experience in the management of these patients in our country. The Drafting Committee emphasizes the need for early identification of HoFH patients, prompt referral to specialized units, and an early and appropriate treatment. These recommendations will provide a guidance for HoFH patient management in Spain.
Filiaciones:
Ascaso, J:
Univ Valencia, INCLIVA, Hosp Clin Univ Valencia, Soc Espanola Arteriosclerosis,Serv Endocrinol & N, Valencia, Spain
Mata, P:
Fdn Hipercolesterolemia Familiar, Madrid, Spain
:
Hosp Clin Univ Valencia, INCLIVA, Serv Hematol & Oncol, Unidad Aferesis, Valencia, Spain
Civeira, F:
Hosp Univ Miguel Servet, Inst Invest Sanitaria Aragon, Serv Med Interna, Unidad Clin & Invest Lipidos & Arteriosclerosis, Zaragoza, Spain
Valdivielso, P:
Univ Malaga, Hosp Univ Virgen de la Victoria, Serv Med Interna, Unidad Lipidos, Malaga, Spain
Masana, L:
Univ Rovira & Virgili, IISPV, Hosp Univ St Joan, Unitat Recerca Lipids & Arteriosclerosi, Tarragona, Spain
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