Molecular sensitization patterns and influence of molecular diagnosis in immunotherapy prescription in children sensitized to both grass and olive pollen
Por:
Martínez-Cañavate Burgos A, Torres-Borrego J, Molina Terán AB, Corzo JL, García BE, Rodríguez Pacheco R, Moreno Aguilar C and Dávila I
Publicada:
1 jun 2018
Ahead of Print:
5 mar 2018
Resumen:
BackgroundThe overlapping grass and olive pollen seasons in Spain and the phenomenon of cross-reactivity can make it difficult to determine the true causative agent of seasonal allergic rhinitis when only skin prick tests with whole extracts are used. The aim of the GRAMOLE study was to determine sensitization patterns to the major grass and olive pollen allergens detected using specific recombinant IgE and to explore how this knowledge affected physicians' choice of allergen-specific immunotherapy.
MethodsEpidemiological, observational, multicenter, cross-sectional study. Results from children under 18years of age diagnosed with seasonal allergic rhinitis by positive skin prick tests to olive and grass pollen were analyzed. Specific IgE to Phl p 1+5, Ole e 1, and Phl p 7+12 was determined. Investigators specified the optimal composition of allergen immunotherapy before and after knowing the results of the molecular diagnosis.
ResultsA total of 281 patients with a mean age of 13.4years were included. Double sensitization to both major allergens was found in vitro in 76% of children for an IgE cutoff point of 0.35kU/L. When the molecular diagnosis results were known, specialists changed the composition of the prescribed immunotherapy in 52.87% of cases.
ConclusionsDouble sensitization to grass and olive pollen is common in Spain and also occurs in the pediatric population. Molecular diagnosis using specific IgE may help improve immunotherapy selection in polysensitized patients.
Filiaciones:
Martínez-Cañavate Burgos A:
Department of Pediatrics, Head of Pediatric Allergy Unit, H. Materno-Infantil Virgen de las Nieves, Granada, Spain
Torres-Borrego J:
Pediatric Allergy and Pulmonology Unit, Reina Sofia Children's University Hospital, Córdoba, Spain
Molina Terán AB:
Pediatric Allergy and Pulmonology Unit, Reina Sofia Children's University Hospital, Córdoba, Spain
Corzo JL:
Pediatric Service, Carlos Haya Hospital, Málaga, Spain
García BE:
Complejo Hospitalario de Navarra, Pamplona, Spain
:
Sección de Alergología. Hospital General Universitario de Elda, Elda (Alicante), Spain
Moreno Aguilar C:
IMIBIC, Hospital Universitario Reina Sofia, ARADYAL, Córdoba, Spain
Dávila I:
Allergy Service and Department of Biomedical and Diagnostics Sciences, Institute for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, Salamanca, Spain
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