COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015): an ongoing global Parkinson's disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation
Por:
Garcia, D, Jesus, S, Aguilar, M, Planellas, L, Caldentey, J, Caballol, N, Legarda, I, Vara, J, Cabo, I, Manzanares, L, Aramburu, I, Rivera, M, Catalan, M, Diaz, L, Puente, V, Moreno, J, Borrue, C, Vila, B, Sauco, M, Vela, L, Escalante, S, Cubo, E, Padilla, F, Castrillo, J, Alonso, P, Losada, M, Ariztegui, N, Gaston, I, Kulisevsky, J, Gonzalez, M, Seijo, M, Martinez, J, Valero, C, Kurtis, M, de Fabregues-Boixar, O, Ardura, J, Jurczynska, C, Martinez-Martin, P, Mir, P, Astrid, D, Almeria, M, Canovas, A, Frech, F, Diaz, A, Arnaiz, S, Arribas, S, Vidondo, A, Lambrich, N, Bejr-Kasem, H, Estrada, M, Boti, M, Gonzalez, C, Lorenzo, A, Carrillo, F, Casas, E, Clavero, P, Fernandez, A, Foraster, A, Cuevas, A, Fonticoba, T, Diez-Fairen, M, Erro, E, Peyret, E, Guillan, N, Gamez, P, Gallego, M, Campos, C, Garre, M, Aloy, J, Garcia, B, Palmas, M, Toledo, G, Diaz, A, Sola, M, Guardia, G, Horta-Barba, A, Infante, J, Labandeira, C, Labrador, M, Lacruz, F, Castro, M, Seoane, B, Macias, Y, Mata, M, Andres, G, Marti, M, McAfee, D, Meitin, M, del Barrio, C, Santiago, J, Casado, M, Dieguez, A, Nogueira, V, Amado, A, Ponte, S, Ordas, C, Pagonabarraga, J, Parees, I, Pascual-Sedano, B, Pastor, P, Fuertes, A, Noguera, R, Prats, M, Morlans, M, Rafales, N, Mendez, L, Perez, A, Roldan, F, De Arcos, M, Sanchez-Carpintero, M, Diez, G, Rodriguez, A, Santacruz, P, Rodriguez, J, Serarols, A, Pena, M, Castro, E, Tartari, J, Vargas, L, Gomez, R, Villanueva, C, Vives, B and Villar, M
Publicada:
1 nov 2019
Ahead of Print:
1 jul 2019
Resumen:
Background and purpose In Parkinson's disease (PD), the course of the disorder is highly variable between patients. Well-designed, prospective studies for identifying PD progression biomarkers are necessary. Our aim was to show the results of baseline evaluations of an ongoing global PD project, COPPADIS-2015 (Cohort of Patients with PArkinson's DIsease in Spain, 2015). Methods This was an observational, descriptive, nationwide study (Spain). The recruitment period ended in October 2017. Baseline evaluation included more than 15 validated scales and complementary studies in a subgroup of participants. Results In total, 1174 subjects from 35 centres were considered valid for baseline analysis: 694 patients (62.6 +/- 8.9 years old, 60.3% males), 273 caregivers (58.5 +/- 11.9 years old, 31.8% males) and 207 controls (61 +/- 8.3 years old, 49.5% males). The mean disease duration was 5.5 +/- 4.4 years. Hoehn and Yahr stage was 1 or 2 in 90.7% of the patients whilst 33.9% and 18.1% of them presented motor fluctuations and dyskinesias, respectively. The mean Non-Motor Symptoms Scale total score was 45.4 +/- 38.1, and 30.4% of the patients presented cognitive impairment, 16.1% major depression, 12.7% impulse control disorder, 7.2% compulsive behaviour, 57.2% pain and 13.2% falls. Compared to the control group, PD patients presented a significantly higher burden of non-motor symptoms and a worse quality of life. More than 300 subjects conducted complementary studies (serum biomarkers, genetic and neuroimaging). Conclusions Parkinson's disease is a complex disorder and different non-motor symptoms are frequently present and are more prevalent than in controls. In real clinical practice it is important to ask for them.
Filiaciones:
Garcia, D:
Chuac, La Coruna, Spain
Jesus, S:
Hosp Univ Virgen del Rocio, Seville, Spain
Aguilar, M:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Planellas, L:
Hosp Clin Barcelona, Barcelona, Spain
Caldentey, J:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Vara, J:
Hosp Univ Vall dHebron, Barcelona, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Manzanares, L:
Hosp Univ La Princesa, Madrid, Spain
Aramburu, I:
Hosp Univ Marques de Valdecilla, Santander, Spain
Rivera, M:
Hosp Gen LHospitalet, Consorci Sanitari Integral, Barcelona, Spain
Catalan, M:
Hosp Univ Clin San Carlos, Madrid, Spain
Diaz, L:
CHUO, Orense, Spain
Puente, V:
Hosp del Mar, Barcelona, Spain
Moreno, J:
Hosp Univ Virgen Macarena, Seville, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Vila, B:
Inst Catala Salut, IAS, Girona, Spain
:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
HTVC, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Padilla, F:
Hosp Univ Canarias, San Cristobal De Laguna, Santa Cruz De T, Spain
Castrillo, J:
Hosp Univ Ramon Y Cajal, Madrid, Spain
Alonso, P:
Hosp Univ Puerta de Hierro, Madrid, Spain
Losada, M:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Ariztegui, N:
Complejo Hosp Toledo, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Gonzalez, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Seijo, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Martinez, J:
Hosp Univ Donostia, San Sebastian, Spain
:
Hosp Arnau Vilanova, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
de Fabregues-Boixar, O:
Hosp Univ Vall dHebron, Barcelona, Spain
Ardura, J:
HULA, Lugo, Spain
Jurczynska, C:
Hosp Rey Juan Carlos, Madrid, Spain
Martinez-Martin, P:
Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid, Spain
Inst Salud Carlos III, CIBERNED, Madrid, Spain
Mir, P:
Hosp Univ Virgen del Rocio, Seville, Spain
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