Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort
Por:
Garcia, D, Fonticoba, T, Castro, E, Borrue, C, Mata, M, Vila, B, Foraster, A, Sauco, M, Perez, A, Vela, L, Macias, Y, Escalante, S, Esteve, P, Villarroya, S, Cubo, E, Casas, E, Arnaiz, S, Padilla, F, Morlans, M, Mir, P, Martinez-Martin, P, Adarmes, A, Almeria, M, Losada, G, Canovas, A, Alonso-Frech, F, Arribas, S, Vidondo, A, Aguilar, M, Avila, M, Lambrich, N, Bejr-Kasem, H, Estrada, M, Boti, M, Gonzalez, C, Lopez, I, Caballol, N, Lorenzo, A, Carrillo, F, Catalan, M, Clavero, P, Fernandez, A, Cuevas, A, de Fabregues-Boixar, O, Diez-Fairen, M, Erro, E, Peyret, E, Guinan, N, Gamez, P, Gallego, M, Caldentey, J, Campos, C, Moreno, J, Gaston, I, Garre, M, Aloy, J, Gonzalez-Aramburu, I, Ardura, J, Garcia, B, Palmas, M, Toledo, G, Diaz, A, Sola, M, Guardia, G, Hernandez-Vara, J, Barba, A, Infante, J, Jesus, S, Kulisevsky, J, Kurtis, M, Labandeira, C, Labrador, M, Lacruz, F, Castro, M, Legarda, I, Ariztegui, N, Diaz, L, Manzanares, L, Seoane, B, Andres, G, Marti, M, Martinez-Castrillo, J, McAfee, D, Meitin, M, Gonzalez, M, del Barrio, C, Santiago, J, Casado, M, Dieguez, A, Nogueira, V, Amado, A, Ponte, S, Ordas, C, Pagonabarraga, J, Parees, I, Pascual-Sedano, B, Pastor, P, Fuertes, A, Noguera, R, Planellas, L, Fuster, J, Prats, M, Jurczynska, C, Puente, V, Rafales, N, Mendez, L, Roldan, F, De Arcos, M, Martinez, J, Alonso, P, Sanchez-Carpintero, M, Diez, G, Rodriguez, A, Santacruz, P, Rodriguez, J, Seijo, M, Serarols, A, Pena, M, Tartari, J, Vargas, L, Gomez, R, Villanueva, C, Vives, B and Villar, M
Publicada:
1 sep 2019
Resumen:
Objective: To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of nondemented Parkinson's disease (PD) patients and compare to a control group.
Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures.
Results: QoL was worse in PD patients (n = 692; 62.6 +/- 8.9 years old, 60.3% males) than controls (n = 206; 61 +/- 8.3 years old, 49.5% males): PDQ-39, 17.1 +/- 13.5 vs 4.4 +/- 6.3 (p < 0.0001); PQ-10, 7.3 +/- 1.6 vs 8.1 +/- 1.2 (p < 0.0001); EUROHIS-Q0L8, 3.8 +/- 0.6 vs 4.2 +/- 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (beta = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait pro- blems contributed the most to global QoL (PQ-10, beta = -0.46 and -0.21, respectively; EUROHIS-QOL8, beta = - 0.44 and - 0.23, respectively).
Conclusions: QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.
Filiaciones:
Garcia, D:
Chuac, La Coruna, Spain
CHUF, Hosp Arquitecto Marcide & Hosp Naval, Ferrol, A Coruna, Spain
Fonticoba, T:
CHUF, Hosp Arquitecto Marcide & Hosp Naval, Ferrol, A Coruna, Spain
Castro, E:
CHUF, Hosp Arquitecto Marcide & Hosp Naval, Ferrol, A Coruna, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Mata, M:
Hosp Infanta Sofia, Madrid, Spain
Vila, B:
IAS, Inst Catala Salud, Girona, Spain
Foraster, A:
IAS, Inst Catala Salud, Girona, Spain
:
Hosp Gen Univ Elche, Elche, Spain
Perez, A:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Hosp HM Puerta Sur, CINAC Ctr Integral Neurociencias AC, Madrid, Spain
Macias, Y:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
HTVC, Tarragona, Spain
Esteve, P:
HTVC, Tarragona, Spain
Villarroya, S:
HTVC, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Casas, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Arnaiz, S:
Complejo Asistencial Univ Burgos, Burgos, Spain
Padilla, F:
Hosp Univ Conarias, San Cristobal De La Lagu, Santa Cruz De T, Spain
Morlans, M:
Hosp Univ Conarias, San Cristobal De La Lagu, Santa Cruz De T, Spain
Mir, P:
Univ Seville, Unidad Trommos Movimiento, Serv Neurol Neumfisiol ClM, Seville, Spain
Martinez-Martin, P:
Inst Salad Carlos III, Ctr Nacl Epidemiol, Madrid, Spain
Inst Salad Carlos III, CIBERNED, Madrid, Spain
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