Consensus on objectives and action guidelines on low density lipoproteins-cholesterol control in very high risk cardiovascular patients
Por:
Galve, E, Guijarro-Herraiz, C, Masana-Marin, L and Cordero-Fort, A
Publicada:
1 ene 2016
Categoría:
Pharmacology (medical)
Resumen:
Introduction: Cardiovascular disease is the leading cause of death in developed countries. Among cardiovascular disease risk factors one of the most relevant is low-density lipoprotein associated cholesterol (LDL-c), but there is controversy about the methods used to control it. The aim was to obtain an expert opinion to clarify the most relevant issues regarding the control of dyslipidemia in very high cardiovascular risk patients.
Materials and methods: A survey with 55 items, stratified into 4 blocks: LDL-c as a therapeutic target, therapeutic goals, causes of the failure to achieve LDL-c goals, and recommendations to optimize their achievement, was addressed to 41 specialists (Cardiology and Internal Medicine) using the Delphi method to achieve professional consensus criteria.
Results: A high consensus was reached among all items, in line with the European recommendations. The panelists considered that the goal of 70 mg/dl for LDL-c for high cardiovascular disease risk (mainly vascular disease, diabetes mellitus, and renal failure), using combined treatment when necessary. Lack of adherence and therapeutic inertia were considered the main reasons for treatment failure.
Conclusion: The Spanish experts show an elevated consensus with the European recommendations, confirming the LDL-c control target of < 70 mg/dl. The simplification of the guidelines and the combined treatment may favor an improvement the achievement of lipid target goals. (C) 2015 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Galve, E:
Hosp Valle De Hebron, Serv Cardiol, Barcelona, Spain
Soc Espanola Cardiol, Secc Riesgo Vasc & Rehabil, Madrid, Spain
Guijarro-Herraiz, C:
Univ Rey Juan Carlos, Hosp Univ Fdn Alcorcon, Serv Med Interna, Madrid, Spain
Soc Espanola Arteriosclerosis, Grp Trabajo, Barcelona, Spain
Masana-Marin, L:
Soc Espanola Arteriosclerosis, Grp Trabajo, Barcelona, Spain
Univ Rovira & Virgili, Hosp Univ St Joan Reus, Unitat Med Vasc & Metab, IISPV,CIBERDEM, Tarragona, Spain
:
Soc Espanola Cardiol, Secc Riesgo Vasc & Rehabil, Madrid, Spain
Hosp Univ San Juan Alicante, Alicante, Spain
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