Relevance of Dementia in Atrial Fibrillation Patients within a Specific European Health Care Area
Por:
Rodriguez-Manero, M, Lopez-Pardo, E, Cordero, A, Kreidieh, O, Platas, J, Valdes, L, Cid-Menendez, A, Garcia-Seara, J, Pereira-Vazquez, M, Martinez-Sande, J, Ruano, A, Pena-Gil, C, Mazon, P, Garcia-Acuna, J and Gonzalez-Juanatey, J
Publicada:
1 ene 2018
Categoría:
Neurology (clinical)
Resumen:
Introduction: Atrial fibrillation might increase the risk of dementia. We aim to test the hypothesis that dementia could reclassify the actual risk of stroke and death predicted by the CHA(2)DS(2)-VASc in patients with atrial fibrillation (AF). Methods: A prospective study performed in a specific health care area. Results: From our health care area (n = 348,985), throughout 2013, AF was codified in 7,990 (2.08%). Mean age was 76.83 +/- 10.5, mean CHA(2)DS(2)-VASc = 3.5, 4,056 (50.8%) were females and 287 (3.6%) were diagnosed to have dementia. Patients with dementia were older and presented a higher rate of all the components of the CHA(2)DS(2)-VASc-expect vasculopathy. Differences in overall mortality were observed but not in stroke and haemorrhagic events. After propensity score matched analysis, dementia was independently associated with all-cause mortality. Addition of dementia to CHA(2)DS(2)-VASc reclassified 7.7 and 16.6% of the cohort with regard to thromboembolic events and death risk respectively. Conclusions: Patients with dementia presented a more adverse risk profile, with significant differences in all-cause mortality. (C) 2018 S. Karger AG, Basel.
Filiaciones:
Rodriguez-Manero, M:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Lopez-Pardo, E:
Hosp Univ Santiago de Compostela, Xerencia Xest Integrada, Santiago De Compostela, Spain
:
Hosp Univ San Juan Alicante, Alicante, Spain
Kreidieh, O:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Platas, J:
Hosp Univ Santiago de Compostela, Xerencia Xest Integrada, Santiago De Compostela, Spain
Valdes, L:
Hosp Univ Santiago de Compostela, Xerencia Xest Integrada, Santiago De Compostela, Spain
Cid-Menendez, A:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Garcia-Seara, J:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Pereira-Vazquez, M:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Martinez-Sande, J:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Ruano, A:
Hosp Univ Santiago de Compostela, Xerencia Xest Integrada, Santiago De Compostela, Spain
Pena-Gil, C:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Mazon, P:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Garcia-Acuna, J:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
Gonzalez-Juanatey, J:
Hosp Univ Santiago De Compostela, CIBERCV Ctr Invest Biomed Red Enfermedad Cardiova, Serv Cardiol, IDIS, Santiago De Compostela, Spain
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