Prediction of major adverse cardiac, cerebrovascular events in patients with diabetes after acute coronary syndrome
Por:
Baluja, A, Rodriguez-Manero, M, Cordero, A, Kreidieh, B, Iglesias-Alvarez, D, Garcia-Acuna, J, Martinez-Gomez, A, Agra-Bermejo, R, Alvarez-Rodriguez, L, Abou-Jokh, C, Lopez-Raton, M, Gude-Sampedro, F, Alvarez-Escudero, J and Gonzalez-Juanatey, J
Publicada:
1 ene 2020
Ahead of Print:
1 dic 2019
Resumen:
Background and objectives: The risk of major adverse cardiac and cerebrovascular events following acute coronary syndrome is increased in people with diabetes. Predicting out-of-hospital outcomes upon follow-up remains difficult, and no simple, well-validated tools exist for this population at present. We aim to evaluate several factors in a competing risks model for actionable evaluation of the incidence of major adverse cardiac and cerebrovascular events in diabetic outpatients following acute coronary syndrome. Methods: Retrospective analysis of consecutive patients admitted for acute coronary syndrome in two centres. A Fine-Gray competing risks model was adjusted to predict major adverse cardiac and cerebrovascular events and all-cause mortality. A point-based score is presented that is based on this model. Results: Out of the 1400 patients, there were 783 (55.9%) with at least one major adverse cardiac and cerebrovascular event (417 deaths). Of them, 143 deaths were due to non-major adverse cardiac and cerebrovascular events. Predictive Fine-Gray models show that the 'PG-HACKER' risk factors (gender, age, peripheral arterial disease, left ventricle function, previous congestive heart failure, Killip class and optimal medical therapy) were associated to major adverse cardiac and cerebrovascular events. Conclusion: The PG-HACKER score is a simple and effective tool that is freely available and easily accessible to physicians and patients. The PG-HACKER score can predict major adverse cardiac and cerebrovascular events following acute coronary syndrome in patients with diabetes.
Filiaciones:
Baluja, A:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Complejo Hosp Univ, Crit Patient Translat Res Grp, Dept Anesthesiol Intens Care & Pain Management, Santiago De Compostela, Spain
Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain
Rodriguez-Manero, M:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Hosp Univ San Juan, Dept Cardiol, Alicante, Spain
Kreidieh, B:
Univ Miami, JFK Med Ctr, Palm Beach Reg GME Consortium, Atlantis, FL USA
Iglesias-Alvarez, D:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Garcia-Acuna, J:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Martinez-Gomez, A:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Agra-Bermejo, R:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Alvarez-Rodriguez, L:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Abou-Jokh, C:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Lopez-Raton, M:
Galician Govt, Board Educ, Xunta De Galicia, Spain
Gude-Sampedro, F:
Univ Clin Hosp Santiago, Clin Epidemiol Unit, Santiago De Compostela, Spain
Alvarez-Escudero, J:
Complejo Hosp Univ, Crit Patient Translat Res Grp, Dept Anesthesiol Intens Care & Pain Management, Santiago De Compostela, Spain
Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain
Gonzalez-Juanatey, J:
Complejo Hosp Univ Santiago de Compostela, Dept Cardiol, Travesia Choupana S-N, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
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