Obesity-Hypoventilation Syndrome: Baseline Hemodynamic Status and Impact of non-Invasive Ventilation
Por:
Fernández Álvarez R, Belda Ramirez J, Rubinos Cuadrado G, Buchelli Ramirez H, Fole Vazquez D, Iscar Urrutia M, Rodriguez Jerez F, Vazquez Lopez MJ and Casan Clara P
Publicada:
1 jul 2020
Ahead of Print:
25 dic 2019
Categoría:
Pulmonary and respiratory medicine
Resumen:
Introduction: Obesity-hypoventilation syndrome (OHS) is a risk factor for heart failure (HF). Some studies associate the use of non-invasive ventilation (NIV) with changes in hemodynamic parameters. Our objective was to describe the hemodynamic status of a group of patients with OHS and to study the effect of NIV.
Patients and methods: Patients with stable OHS treated with NIV were included in this cross-sectional repeated measurements study. Hemodynamics were measured by bioimpedance: 30 minutes at baseline and another 30 minutes on NIV. Cardiac output (CO), cardiac index, and systolic volume were measured. The CO calculated for each patient expressed as a percentage of the lower limit of normal (LLN) was taken as reference, and 2 groups were formed: patients without HF and normal CO ( > 100% of LLN) and patients with HF and low CO (< 100% of LLN). The Mann-Whitney U test was used to compare independent variables and the Wilcoxon test was used for paired variables, with significance set at P<.05.
Results: The final sample comprised 36 patients, aged 66 (+/-8) years, 19 (52%) men. In 17 (46%) patients, HF was detected with a CO of 3.71/min (66%) compared to the group without HF, whose CO was 71/min (107%). After NIV, patients with HF showed improvement in CO (4.51/min (77%), P=.009, while the non-HF group remained unchanged, with CO 6.81/min (104%), P=.2.
Conclusion: A total of 46% of patients with stable OHS present HF; NIV improves hemodynamics and does not affect patients with normal CO. (C) 2020 SEPAR. Published by Elsevier Espafia, S.L.U. All rights reserved.
Filiaciones:
Fernández Álvarez R:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
:
Servicio de Neumología. Hospital Arnau de Vilanova, Valencia
Rubinos Cuadrado G:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
Buchelli Ramirez H:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
Fole Vazquez D:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
Iscar Urrutia M:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
Rodriguez Jerez F:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
Vazquez Lopez MJ:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
Casan Clara P:
Servicio de Neumología, Área de Pulmón, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
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