Salivary microbiome composition changes after bariatric surgery
Por:
Džunková M, Lipták R, Vlková B, Gardlík R, Cierny M, Moya A and Celec P
Publicada:
18 nov 2020
Ahead of Print:
18 nov 2020
Categoría:
Multidisciplinary
Resumen:
Recent studies show that the salivary microbiome in subjects with obesity differ from those without obesity, but the mechanism of interaction between the salivary microbiome composition and body weight is unclear. Herein we investigate this relation by analyzing saliva samples from 35 adult patients with obesity undergoing bariatric surgery. Our aim was to describe salivary microbiome changes during body weight loss on an individual-specific level, and to elucidate the effect of bariatric surgery on the salivary microbiome which has not been studied before. Analysis of samples collected before and 1 day after surgery, as well as 3 and 12 months after surgery, showed that the salivary microbiome changed in all study participants, but these changes were heterogeneous. In the majority of participants proportions of Gemella species, Granulicatella elegans, Porphyromonas pasteri, Prevotella nanceiensis and Streptococcus oralis decreased, while Veillonella species, Megasphaera micronuciformis and Prevotella saliva increased. Nevertheless, we found participants deviating from this general trend which suggests that a variety of individual-specific factors influence the salivary microbiome composition more effectively than the body weight dynamics alone. The observed microbiome alternations could be related to dietary changes. Therefore, further studies should focus on association with altered taste preferences and potential oral health consequences.
Filiaciones:
:
Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Lipták R:
Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Vlková B:
Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Gardlík R:
Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Cierny M:
Department of Bariatric Surgery, Breclav Hospital, Breclav, Czech Republic
:
Department of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencian Community (FISABIO-Public Health), Valencia, Spain.
CIBER in Epidemiology and Public Health (CIBEResp), Madrid, Spain.
Institute for Integrative Systems Biology (I2SysBio), University of Valencia and Spanish National Research Council (CSIC), València, Spain.
Celec P:
Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Green Published, gold, Green Submitted
|