Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues
Por:
Sanz-González SM, García-Medina JJ, Zanón-Moreno V, López-Gálvez MI, Galarreta-Mira D, Duarte L, Valero-Velló M, Ramírez AI, Arévalo JF, Pinazo-Durán MD and On Behalf Of The Valencia Study Group On Diabetic Retinopathy Vsdr Report Number
Publicada:
1 nov 2020
Ahead of Print:
9 nov 2020
Resumen:
Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/omega 3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (-) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/omega 3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM - DR (p < 0.05). The A/omega 3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/omega 3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness.
Filiaciones:
:
Ophthalmic Research Unit "Santiago Grisolía", Fundación Investigación Sanitaria y Biomédica (FISABIO), Ave. Gaspar Aguilar 90, 46017 Valencia, Spain
Cellular and Molecular Ophthalmo-Biology Group, University of Valencia, Ave. Blasco Ibañez 15, 46010 Valencia, Spain
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
:
Ophthalmic Research Unit "Santiago Grisolía", Fundación Investigación Sanitaria y Biomédica (FISABIO), Ave. Gaspar Aguilar 90, 46017 Valencia, Spain
Cellular and Molecular Ophthalmo-Biology Group, University of Valencia, Ave. Blasco Ibañez 15, 46010 Valencia, Spain
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
Department of Ophthalmology, General University Hospital Morales Meseguer, Ave. Marques de los Velez, s/n 30008 Murcia, Spain
Department of Ophthalmology and Optometry, University of Murcia, Edificio LAIB Planta 5ª, Carretera Buenavista s/n, 30120 El Palmar Murcia, Spain
:
Ophthalmic Research Unit "Santiago Grisolía", Fundación Investigación Sanitaria y Biomédica (FISABIO), Ave. Gaspar Aguilar 90, 46017 Valencia, Spain
Cellular and Molecular Ophthalmo-Biology Group, University of Valencia, Ave. Blasco Ibañez 15, 46010 Valencia, Spain
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
Area of Health, Valencian International University, Calle Pintor Sorolla 21, 46002 Valencia, Spain
López-Gálvez MI:
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
Department of Ophthalmology, The University Clinic Hospital, Ave. Ramón y Cajal 3, 47003 Valladolid, Spain
Galarreta-Mira D:
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
Department of Ophthalmology, The University Clinic Hospital, Ave. Ramón y Cajal 3, 47003 Valladolid, Spain
Duarte L:
Department of Ophthalmology, Complexo Hospitalar "Entre Douro e Vouga", 4520-211 Santa Maria da Feira, Portugal
:
Ophthalmic Research Unit "Santiago Grisolía", Fundación Investigación Sanitaria y Biomédica (FISABIO), Ave. Gaspar Aguilar 90, 46017 Valencia, Spain
Ramírez AI:
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
Department of Immunology, Ophthalmology and Otorrinolaringology, Faculty of Optics and Optometry, Universidad Complutense, Calle Arcos de Jalón 118, 28037 Madrid, Spain
Instituto de Investigaciones Oftalmológicas "Ramón Castroviejo", Faculty of Medicine, Universidad Complutense, Plaza Ramón y Cajal, s/n 28040 Madrid, Spain
Arévalo JF:
Wilmer s Eye Institute at the Johns Hopkins Hospital, Baltimore, MD 21287, USA
:
Ophthalmic Research Unit "Santiago Grisolía", Fundación Investigación Sanitaria y Biomédica (FISABIO), Ave. Gaspar Aguilar 90, 46017 Valencia, Spain
Cellular and Molecular Ophthalmo-Biology Group, University of Valencia, Ave. Blasco Ibañez 15, 46010 Valencia, Spain
Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain
Green Published, gold, Green Accepted
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