Clinically significant renal involvement in primary Sjogren's syndrome is associated with important morbidity: data from the Spanish Sjogrenser cohort
Por:
Narvaez, J, Sanchez-Piedra, C, Fernandez-Castro, M, Martinez-Taboada, V, Olive, A, Rosas, J, Garcia-Vadillo, J, Judez, E, Ruiz-Lucea, E, Romani, L, Montala, N and Andreu, J
Publicada:
1 ene 2020
Resumen:
Objective. To investigate the prevalence, associated factors, and effects of primary overt renal disease on morbidity in patients with primary Sjogren's syndrome (pSS).
Methods. All patients in the Sjogrenser (registry of adult pSS patients of the Spanish Society of Rheumatology) cohort were retrospectively investigated for the presence of clinically significant renal involvement directly related to pSS activity.
Results. Of the 437 patients investigated, 39 (9%) presented overt renal involvement during follow-up. Severe renal disease necessitating kidney biopsy was relatively rare (2%).
Renal involvement may complicate pSS at any time during the disease course and is associated with severe disease (indicated by higher scores of involvement, activity, and damage), systemic multiorgan involvement, and a higher frequency of lymphoma. Multivariate analysis showed that older age (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.00-1.07), higher European League Against Rheumatism Sjogren's Syndrome Disease Activity Index scores (OR 1.1, CI 1.03-1.18), serum anti-La/SSB positivity (OR 6.65, CI 1.41-31.372), and non-vasculitic cutaneous involvement (OR 5.47, 1.03-29.02) were independently associated with this complication.
Chronic renal failure developed in 23 of 39 patients (59%); only 1 of them progressed to end-stage renal disease necessitating renal replacement therapy. Patients with overt renal disease showed higher Sjogren's syndrome disease damage index scores, higher rates of hospitalisation due to disease activity and higher rates of clinically relevant comorbidities.
Conclusion. Overt renal involvement in pSS is not uncommon. Although it usually shows a favourable prognosis, is associated with significant morbidity.
Filiaciones:
Narvaez, J:
Hosp Univ Bellvitge, Dept Rheumatol, Planta 10-2,Feixa Llarga S-N, Barcelona 08907, Spain
Sanchez-Piedra, C:
Sociedad Espanola Reumatol, Unidad Invest, Madrid, Spain
Fernandez-Castro, M:
Hosp Puerto Hierro, Dept Rheumatol, Madrid, Spain
Martinez-Taboada, V:
Hosp Marques Valdecilla, Dept Rheumatol, Santander, Spain
Olive, A:
Hosp Badalona Germans Trias & Pujol, Dept Rheumatol, Barcelona, Spain
:
Hosp Marina Baixa, Dept Rheumatol, Alicante, Spain
Garcia-Vadillo, J:
Hosp Princesa, Dept Rheumatol, Madrid, Spain
Judez, E:
Hosp Albacete, Rheumatol Unit, Albacete, Spain
Ruiz-Lucea, E:
Hosp Basurto, Dept Rheumatol, Vizcaya, Spain
Romani, L:
Hosp Virgen de las Nieves, Dept Rheumatol, Granada, Spain
Montala, N:
Hosp Santa Maria, Dept Rheumatol, Lleida, Spain
Andreu, J:
Hosp Puerto Hierro, Dept Rheumatol, Madrid, Spain
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