Digestive involvement in primary Sjögren's syndrome: analysis from the Sjögrenser registry.
Por:
Melchor, S, Sanchez-Piedra, C, Castro, M, Andreu, J, Taboada, V, Olive, A, Rosas, J, Menor, R, Garcia-Aparicio, A, Longo, F, Manrique-Arija, S, Vadillo, J, Lopez-Gonzalez, R, Narvaez, J, Galisteo, C, Martin, J, Naranjo, A, Illera, O, Moreira, B, Raya, E, Lopez, M, Judez, E, Moriano, C, Torrente-Segarra, V, Magallon, B, Astete, C, Castellvi, I, Bohorquez, C, Loricera, J, Belzunegui, J, Carreira, P and Spanish Soc Rheumatology Systemic
Publicada:
1 oct 2020
Ahead of Print:
1 oct 2020
Resumen:
OBJECTIVES: Digestive involvement (DI) has been reported in 10-30% of primary Sjögren's syndrome (pSS) patients, and few studies have systematically analysed the prevalence of DI in pSS patients. The aim of this study was to describe DI prevalence in pSS patients from the Sjögrenser Study, and to analyse its clinical associations. METHODS: All patients included in the Sjögrenser study, a Spanish multicentre randomised cohort, containing demographic, clinical and histologic data, have been analysed retrospectively. Patients were classified according to the presence of DI (oesophageal, gastric, intestinal, hepatic and pancreatic), and we have performed DI clinical associations, descriptive statistics, Student t or ?2 test, and uni and multivariate logistic regression. RESULTS: From 437 included patients, 95% were women, with a median age of 58 years, 71 (16.2%) presented DI: 21 (29.5%) chronic atrophic gastritis, 12 (16.9%) oesophageal motility dysfunction, 3 (4.2%) lymphocytic colitis, 18 (25.3%) primary biliary cholangitis, 15 (21.1%) autoimmune hepatitis, 7 (9.8%) pancreatic involvement and 5 (7%) coeliac disease. Half of them developed DI at the same time or after pSS diagnosis. Patients with DI were significantly older at pSS diagnosis (p=0.032), more frequently women (p=0.009), presented more autoimmune hypothyroidism and C3 hypocomplementaemia (p=0.040), and were treated more frequently with glucocorticoids, immunosuppressant and biologic therapies. Patients with pancreatic involvement presented more central nervous system and renal involvement, Raynaud's phenomenon, lymphoma and C3/C4 hypocomplementaemia. CONCLUSIONS: DI is frequent in Sjögrenser patients, mainly in the form of autoimmune disorders, and seem to be associated with a more severe phenotype. Our results suggest that DI should be evaluated in pSS patients, especially those with more severe disease.
Filiaciones:
Melchor, S:
Hosp Univ Doce Octubre, Rheumatol Dept, Madrid, Spain
Sanchez-Piedra, C:
SER, Unidad Invest, Madrid, Spain
Castro, M:
Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain
Andreu, J:
Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain
Taboada, V:
Univ Cantabria, Fac Med, Hosp Univ Marques Valdecilla, Santander, Spain
Olive, A:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
:
Hosp Marina Baixa, Alicante, Spain
Menor, R:
Hosp Gen Jerez de la Frontera, Cadiz, Spain
Garcia-Aparicio, A:
Hosp Virgen de la Salud, Toledo, Spain
Longo, F:
Hosp Univ Gregorio Maranon, Madrid, Spain
Manrique-Arija, S:
Hosp Univ Carlos Haya, Malaga, Spain
Vadillo, J:
Hosp Univ Princesa, Madrid, Spain
Lopez-Gonzalez, R:
Hosp Virgen de la Concha, Zamora, Spain
Narvaez, J:
Hosp Univ Bellvitge, Barcelona, Spain
Galisteo, C:
Hosp Univ Parc Tauli, Barcelona, Spain
Martin, J:
Hosp Univ Madrid Norte Sanchinarro, Madrid, Spain
Naranjo, A:
Hosp Univ Doctor Negrin, Las Palmas Gran Canaria, Spain
Illera, O:
Hosp Univ Infanta Sofia, Madrid, Spain
Moreira, B:
Complejo Hosp Pontevedra, Pontevedra, Spain
Raya, E:
Hosp Clin Univ San Cecilio, Granada, Spain
Lopez, M:
Hosp Meixoeiro, Vigo, Spain
Judez, E:
Hosp Univ Albacete, Albacete, Spain
Moriano, C:
Hosp Univ Leon, Leon, Spain
Torrente-Segarra, V:
Hosp Gen Hosp, Barcelona, Spain
Magallon, B:
Hosp Univ Miguel Servet, Zaragoza, Spain
Astete, C:
Hosp Univ Ramon & Cajal, Madrid, Spain
Castellvi, I:
Hosp Univ Santa Creu & St Pau, Barcelona, Spain
Bohorquez, C:
Hosp Univ Principe Asturias, Madrid, Spain
Loricera, J:
Univ Cantabria, Fac Med, Hosp Univ Marques Valdecilla, Santander, Spain
Belzunegui, J:
Hosp Univ Donostia, Guipuzcoa, Spain
Carreira, P:
Hosp Univ Doce Octubre, Rheumatol Dept, Madrid, Spain
Open Access
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