No radiographic sacroiliitis progression was observed in patients with early spondyloarthritis at 6 years: results of the Esperanza multicentric prospective cohort
Por:
Fernandez C, Tornero C, Castro-Villegas MC, Galindez E, García-Llorente JF, García-Vivar ML, Joven-Ibáñez B, Juanola X, Urrego-Laurín C, López-Medina C, Almodovar R, Martínez-Alberola N, Ruiz-Jimeno T, de Miguel E and ESPERANZA study group
Publicada:
1 sep 2020
Resumen:
Objective To estimate the 6-year radiographic progression of sacroiliitis in patients with early spondyloarthritis (SpA). Patients and methods Sacroiliac joint (SIJ) radiographs (baseline and 6 years) of 94 patients with recent-onset SpA from the Esperanza cohort were scored, blindly and in a random order, by nine readers. The modified New York criteria were used to define the presence of sacroiliitis. As the gold standard for radiographic (r) sacroiliitis, the categorical opinion of at least five readers was used. Progression was defined as the shift from non-radiographic (nr) to r-sacroiliitis. Results In the 94 SIJ radiographs (baseline and 6 years), 78/94 (83%) pairs of radiographs had not changed from baseline to 6 years. Sacroiliitis was present in 20 patients at baseline (21.3%) and in 18 (19.2%) patients at 6 years; 11 patients had sacroiliitis at both the baseline and final visits; 9 patients changed from baseline r-sacroiliitis to nr-sacroiliitis at 6 years, and 7 changed from baseline nr-sacroiliitis to r-sacroiliitis at 6 years. The mean continuous change score (range: -8 to +8) was 2.80 at baseline and 2.55 at 6 years (mean net progression of -0.25). The reliability of the readers was fair (mean inter-reader kappa of 0.375 (0.146-0.652) and mean agreement of 73.7% (58.7-90%)). Conclusion In the early SpA Esperanza cohort, progression from nr-axSpA to r-axSpA over 6 years was not observed, although the SIJ radiographs scoring has limitations to detect low levels of radiographic progression.
Filiaciones:
Fernandez C:
Rheumatology Department, Hospital Universitario San Juan de Alicante, Alicante, Spain
Tornero C:
Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain
Castro-Villegas MC:
Rheumatology Department, Hospital Universitario Reina Sofía/IMIBIC, Cordoba, Spain
Galindez E:
Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain
García-Llorente JF:
Rheumatology Department, Hospital de Galdakao Usansolo, Bilbao, Spain
García-Vivar ML:
Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain
Joven-Ibáñez B:
Rheumatology Department, Hospital 12 de Octubre, Madrid, Spain
Juanola X:
Rheumatology Department, Hospital Universitari de Bellvitge/IDIBELL, Barcelona, Spain
Urrego-Laurín C:
Rheumatology Department, Hospital Universitario Moncloa, Madrid, Spain
López-Medina C:
Rheumatology Department, Hôpital Cochin, Paris, France
Almodovar R:
Rheumatology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain
:
Rheumatology Department, Hospital Universitario de Elda, Elda, Spain
Ruiz-Jimeno T:
Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain
de Miguel E:
Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain
Green Published, gold
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