Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
Por:
Genre, F, Rueda-Gotor, J, Remuzgo-Martinez, S, Pulito-Cueto, V, Corrales, A, Mijares, V, Lera-Gomez, L, Portilla, V, Exposito, R, Mata, C, Blanco, R, Llorca, J, Hernandez-Hernandez, V, Vicente, E, Fernandez C, Martinez-Vidal, M, Castro-Corredor, D, Anino-Fernandez, J, Rodriguez-Lozano, C, Gualillo, O, Quevedo-Abeledo, J, Castaneda, S, Ferraz-Amaro, I, Lopez-Mejias, R and Gonzalez-Gay, M
Publicada:
15 jun 2020
Categoría:
Multidisciplinary
Resumen:
Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA.
Filiaciones:
Genre, F:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Rueda-Gotor, J:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Remuzgo-Martinez, S:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Pulito-Cueto, V:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Corrales, A:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Mijares, V:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Lera-Gomez, L:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Portilla, V:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Exposito, R:
Hosp Comarcal Laredo, Rheumatol Div, Laredo, Spain
Mata, C:
Hosp Comarcal Laredo, Rheumatol Div, Laredo, Spain
Blanco, R:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Llorca, J:
Univ Cantabria, Sch Med, Dept Epidemiol & Computat Biol, Santander, Spain
IDIVAL, CIBERESP, Santander, Spain
Hernandez-Hernandez, V:
Hosp Univ Canarias, Rheumatol Div, Santa Cruz De Tenerife, Spain
Vicente, E:
Hosp Univ La Princesa, Rheumatol Div, IIS Princesa, Madrid, Spain
Fernandez C:
Hosp Univ San Juan, Rheumatol Div, Alicante, Spain
Martinez-Vidal, M:
Hosp Gen Univ Alicante, Rheumatol Div, Alicante, Spain
Castro-Corredor, D:
Hosp Gen Univ Ciudad Real, Rheumatol Div, Ciudad Real, Spain
Anino-Fernandez, J:
Hosp Gen Univ Ciudad Real, Rheumatol Div, Ciudad Real, Spain
Rodriguez-Lozano, C:
Hosp Univ Gran Canaria Dr Negrin, Rheumatol Div, Las Palmas Gran Canaria, Spain
Gualillo, O:
Santiago Univ Clin Hosp, NEIRID Grp, SERGAS & IDIS, Santiago De Compostela, Spain
Quevedo-Abeledo, J:
Hosp Univ Gran Canaria Dr Negrin, Rheumatol Div, Las Palmas Gran Canaria, Spain
Castaneda, S:
Hosp Univ La Princesa, Rheumatol Div, IIS Princesa, Madrid, Spain
Ferraz-Amaro, I:
Hosp Univ Canarias, Rheumatol Div, Santa Cruz De Tenerife, Spain
Lopez-Mejias, R:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Gonzalez-Gay, M:
IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst Di, Santander, Spain
Univ Cantabria, Sch Med, Santander, Spain
gold, Green Published
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