Arterial stiffness in normotensive and hypertensive subjects: Frequency in community pharmacies
Por:
Rodilla Sala E, Adell Alegre M, Giner Galvañ V, Perseguer Torregrosa Z, Pascual Izuel JM and Climent Catalá MT
Publicada:
7 dic 2017
Ahead of Print:
12 jul 2017
Categoría:
Medicine (miscellaneous)
Resumen:
Background and objective: Arterial stiffness (AS) is a well-recognized target organ lesion. This study aims to determine: 1) the frequency of AS in community pharmacies: 2) if stiffened subjects identified by brachial oscillometry have more CV risk factors than normal subjects, and 3) the dependence of stiffness on using either age-adjusted values or a fixed threshold.
Patients and method: Observational, cross-sectional study in 32 community pharmacies of the Valencia Community, between November/2015 and April/2016. Stiffness was as pulse wave velocity (PWV) measured with a semi-automatic, validated device (Mobil-O-Graph (R), IEM), followed by a 10-item questionnaire.
Results: Mean age of the 1,427 consecutive recruited patients was 56.6 years. Overall proportion of patients with AS was 17.4% with age-adjusted PWV (9.4% in normotensives, 28.3% in hypertensives). Multivariate logistic regression showed independent association of stiffness in normotensives with male gender, obesity, higher pulse pressure and heart rate, in hypertensives, with higher pulse pressure and lower age. AS was globally found in 20.5% of subjects, defining stiffness by PWV > 10 m/s (6.2% in normotensives, 40.2% in hypertensives). It was associated with higher age and pulse pressure in both groups. Concordance in classifying stiffness was 74.6%.
Conclusions: Frequency of AS varied between 17.4-20.5%. Age-adjusted stiffness is associated in normotensives with male gender, pulse pressure, obesity and heart rate, in hypertensives with pulse pressure and inversely to age. Stiffness by 10 m/s is determined by higher pulse pressure and higher age. Both definitions of PWV are not interchangeable. (C) 2017 Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
:
Unidad de HTA y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Sagunto, Valencia, España
Universidad CEU Cardenal Herrera, Área de Ciencias de la Salud de Moncada, Moncada, Valencia, España
Adell Alegre M:
Sociedad Española de Farmacia Familiar y Comunitaria de la Comunitat Valenciana, Valencia, España
:
Unidad de HTA y Riesgo Cardiometabólico, Servicio de Medicina Interna, Hospital Verge dels Lliris, Alcoi, Alicante, España
Perseguer Torregrosa Z:
Sociedad Española de Farmacia Familiar y Comunitaria de la Comunitat Valenciana, Valencia, España
Pascual Izuel JM:
Unidad de HTA y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Sagunto, Valencia, España
Climent Catalá MT:
Sociedad Española de Farmacia Familiar y Comunitaria de la Comunitat Valenciana, Valencia, España
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