Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
Por:
Rubín-García M, Vitelli-Storelli F, Molina AJ, Zamora-Ros R, Aragonés N, Adarnaz E, Castaño-Vinyals G, Obón-Santacana M, Gómez-Acebo I, Molina-Barceló A, Fernández-Tardón G, Jiménez-Moleón JJ, Alguacil J, Chirlaque MD, Toledo E, Pérez-Gómez B, Pollán M, Kogevinas M and Martín V
Publicada:
1 nov 2020
Ahead of Print:
26 oct 2020
Resumen:
Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
Filiaciones:
Rubín-García M:
Group of Investigation in Interactions Gene-Environment and Health (GIIGAS)
Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain
Vitelli-Storelli F:
Group of Investigation in Interactions Gene-Environment and Health (GIIGAS)
Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain
Molina AJ:
Group of Investigation in Interactions Gene-Environment and Health (GIIGAS)
Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain
Zamora-Ros R:
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, 08908 Barcelona, Spain
Aragonés N:
Department of Health of Madrid, Epidemiology Section, Public Health Division, 28035 Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Adarnaz E:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Department of Preventive Medicine and Public Health, Navarra Institute for Health Research (IdiSNA), University of Navarra, 31008 Pamplona, Spain
Castaño-Vinyals G:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Barcelona Institute for Global Health (ISGlobal), 08036 Barcelona, Spain
Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain
Department of Public Health, Universitat Pompeu Fabra (UPF), Campus del Mar, 08002 Barcelona, Spain
Obón-Santacana M:
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet De Llobregat, 08908 Barcelona, Spain
Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet Del Llobregat, 08908 Barcelona, Spain
Gómez-Acebo I:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Facultad de Medicina, Universidad de Cantabria
IDIVAL, 39011 Santander, Spain
:
Cancer and Public Health Area, FISABIO-Public Health, 46020 Valencia, Spain
Fernández-Tardón G:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Health Research Institute of the Principality of Asturias (ISPA), Oncology Institute, University of Oviedo, 33003 Oviedo, Asturias
Jiménez-Moleón JJ:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada
Universidad de Granada, 18071 Granada, Spain
Alguacil J:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Campus Universitario de El Carmen, 21071 Huelva, Spain
Chirlaque MD:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Campus de Ciencias de la Salud, 30120 El Palmar, Murcia, Spain
Toledo E:
Department of Preventive Medicine and Public Health, Navarra Institute for Health Research (IdiSNA), University of Navarra, 31008 Pamplona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
Pérez-Gómez B:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Cancer and Environmental Epidemiology Unit, Department of Epidemiology and Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro, IDIPHIM, 28222 Madrid, Spain
Pollán M:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Cancer and Environmental Epidemiology Unit, Department of Epidemiology and Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
Kogevinas M:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
Barcelona Institute for Global Health (ISGlobal), 08036 Barcelona, Spain
Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain
Department of Public Health, Universitat Pompeu Fabra (UPF), Campus del Mar, 08002 Barcelona, Spain
Martín V:
Group of Investigation in Interactions Gene-Environment and Health (GIIGAS)
Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
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