Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
Por:
Weitzer J, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, Guevara M, Amiano P, Martín V, Molina-Barceló A, Alguacil J, Moreno V, Suarez-Calleja C, Jiménez-Moleón JJ, Marcos-Gragera R, Papantoniou K, Pérez-Gómez B, Llorca J, Ascunce N, Gil L, Gracia-Lavedan E, Casabonne D, Lope V, Pollán M and Kogevinas M
Publicada:
15 mar 2021
Ahead of Print:
1 oct 2020
Resumen:
Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer prevention.
Filiaciones:
Weitzer J:
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria
Castaño-Vinyals G:
Universitat Pompeu Fabra (UPF), Barcelona, Spain
ISGlobal, Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Aragonés N:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Public Health Division, Department of Health, Epidemiology Section, Madrid, Spain
Gómez-Acebo I:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Universidad de Cantabria - IDIVAL, Santander, Spain
Guevara M:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Navarra Public Health Institute, Pamplona, Spain
Navarra Institute for Health Research (IdisNa), Pamplona, Spain
Amiano P:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain
Martín V:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
The Research Group in Gene - Environment and Health Interactions (GIIGAS) / Institut of Biomedicine (IBIOMED), Universidad de León, León, Spain & Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, Spain
:
Cancer and Public Health Area, FISABIO - Public Health, Valencia, Spain
Alguacil J:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Environmental Epidemiology and Neuroscience Laboratory, RENSMA, Huelva University, Huelva, Spain
Moreno V:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Cancer Epidemiology Research Program, IDIBELL
Catalan Institute of Oncology, Spain
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Suarez-Calleja C:
IUOPA, University of Oviedo and ISPA
Jiménez-Moleón JJ:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Department of Preventive Medicine and Public Health. School of Medicine, University of Granada & Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain
Marcos-Gragera R:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain
Unitat d'Epidemiologia i Registre de Càncer de Girona (UERCG), Pla Director d'Oncologia, Institut Català d'Oncologia, Institut d'Investigació Biomèdica de Girona (IdIBGi), Universitat de Girona, Girona, Spain
Papantoniou K:
Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria
Pérez-Gómez B:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
Cardiovascular & Metabolic Diseases Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Llorca J:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Universidad de Cantabria - IDIVAL, Santander, Spain
Ascunce N:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Navarra Public Health Institute, Pamplona, Spain
Navarra Institute for Health Research (IdisNa), Pamplona, Spain
Gil L:
Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain
Gracia-Lavedan E:
ISGlobal, Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Casabonne D:
Unit of Molecular and Genetic Epidemiology in Infections and Cancer (UNIC-Molecular)
Cancer Epidemiology Research Program, IDIBELL
Catalan Institute of Oncology, Spain
Lope V:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Pollán M:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
Kogevinas M:
Universitat Pompeu Fabra (UPF), Barcelona, Spain
ISGlobal, Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Green Published, hybrid
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