Latent and active tuberculosis infections in migrants and travellers: A retrospective analysis from the Spanish plus REDIVI collaborative network
Por:
Wikman-Jorgensen P, López-Velez R, Llenas-García J, Treviño B, Pascual R, Molina I, Domínguez Á, Torrús D, Ruiz Giardín JM, Monge-Maillo B, Norman FF, Romero M and Perez-Molina JA
Publicada:
1 jul 2020
Ahead of Print:
29 jul 2019
Resumen:
Background: Tuberculosis (TB) is the leading cause of infectious disease mortality worldwide. We analysed active and latent TB infections (LTBI) from the Spanish Network for the Study of Imported Infectious Diseases by Travellers and Immigrants (+REDIVI).
Methods: Observational, retrospective, multicentre study of TB and LTBI registered in the +REDIVI network from October 2009 to December 2016.
Results: Of 1008 cases of LTBI, 884 (87.7%) were immigrants; 93 (4.5%), immigrants visiting friends and relatives (VFR); 2 (0.9%), VFR-travellers; and 29 (1.1%), travellers. Absolute (N = 157 vs. N = 75) and relative (12.5% vs. 5.9%) frequency decreased over the study period (p = 0.003). Median time to diagnosis was 24.6 months (females 50.3 vs males 11.9; p < 0.001).
Of 448 TB cases, 405 (90.4%) were in immigrants; 30 (6.7%), VFR-immigrants; 6 (1.3%), VFR-travellers; and 7 (1.6%), travellers. Median time to diagnosis was 62.5 months (females 86.6 vs males 70.1; p = 0.0075).
There were 8 multidrug resistant TB cases and 1 extensively drug resistant case of TB, all in immigrants.
Conclusion: TB was frequently diagnosed more than 5 years after arrival in Spain. Screening programmes for TB and LTBI in immigrants should be considered beyond this time point. Women showed a higher diagnostic delay for both latent and active TB.
Filiaciones:
:
Hospital General Universitario de Elda, Alicante, Spain
López-Velez R:
National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
:
Hospital Vega Baja, Orihuela, Alicante, Spain
Treviño B:
Unitat Medicina Tropical i Salut Internacional Vall d'Hebron-Drassanes, PROSICS, Barcelona, Spain
:
Hospital General Universitario de Elda, Alicante, Spain
Departamento de Medicina Clinica, Universidad Miguel Hernández, San Juan de Alicante, Spain
Molina I:
Department of Infectious Diseases, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona, PROSICS Barcelona, Barcelona, Spain
Domínguez Á:
Hospital Universitario Virgen de la Macarena de Sevilla, Sevilla, Spain
Torrús D:
Hospital General Universitario de Alicante, Alicante, Spain
Ruiz Giardín JM:
Hospital Universitario de Fuenlabrada, Madrid, Spain
Monge-Maillo B:
National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
Norman FF:
National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
:
Hospital General Universitario de Elda, Alicante, Spain
Perez-Molina JA:
National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
Aguilera P:
Centro de Atención Primaria Guayaba, Comunidad de Madrid, Spain
Serrano MM:
Complejo Hospitalario Universitario de Albacete, Comunidad de Castilla-La Mancha, Spain
Rodriguez MG:
Consorcio Hospital General Universitario de Valencia, Comunidad Valenciana, Spain
Menendez MD:
Hospital Carlos III-La Paz, Comunidad de Madrid, Spain
Meije Y:
Hospital de Barcelona, Cataluña, Spain
Martínez-Montauti J:
Hospital de Barcelona, Cataluña, Spain
Sanz X:
Hospital de Barcelona, Cataluña, Spain
:
Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
:
Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
López BM:
Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
:
Hospital General de Elche, Comunidad Valenciana, Spain
:
Hospital General de Elche, Comunidad Valenciana, Spain
Ramos J:
Hospital General Universitario de Alicante, Comunidad Valenciana, Spain
Malmierca E:
Hospital Infanta Sofía, Comunidad de Madrid, Spain
Suárez-García I:
Hospital Infanta Sofía, Comunidad de Madrid, Spain
Perez-Ayala A:
Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
Herrero JM:
Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
Lizasoain M:
Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
Rojo P:
Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
Zarco C:
Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
Rodriguez-Guardado A:
Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
Suárez JF:
Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
Boga Ribeiro JA:
Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
Agirre JG:
Hospital Universitario Cruces de Barakaldo, Bilbao, España País Vasco, Spain
Zubero Sulibarría MZ:
Hospital Universitario de Basurto de Bilbao, País Vasco, Spain
Sanmartín López JV:
Hospital Universitario de Fuenlabrada, Comunidad de Madrid, Spain
Arribas MV:
Hospital Universitario Fundación de Alcorcón, Comunidad de Madrid, Spain
Muñoz EC:
Hospital Universitario La Fe de Valencia, Comunidad Valenciana, Spain
Ribas AM:
Hospital Universitario Son Espases, Islas Baleares, Spain
Vera MP:
Hospital Universitario Son Espases, Islas Baleares, Spain
Montalvá AS:
Hospital Universitario Vall d'Hebron, Cataluña, Spain
Salvador F:
Hospital Universitario Vall d'Hebron, Cataluña, Spain
Moreno L:
Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Comunidad de Madrid, Spain
Henríquez-Camacho C:
Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Comunidad de Madrid, Spain
Delcor NS:
Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
Soriano-Arandes A:
Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
Souto IO:
Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
Ciruelo DP:
Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
Bocanegra C:
Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
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