Characteristics and outcome of patients with solid tumour requiring admission to the intensive care unit. Usefulness of three severity score systems.
Por:
Pérez Pérez ML, Gonzaga López A, Balandín Moreno B, Maximiano Alonso C, Palacios Castañeda D, Ferreres Franco J, García Sanz J, Villanueva Fernández H, Valdivia de la Fuente M, Ortega López A, Alcántara Carmona S, Pérez Redondo M and Royuela Vicente A
Publicada:
11 oct 2019
Ahead of Print:
9 mar 2019
Categoría:
Medicine (miscellaneous)
Resumen:
BACKGROUND AND OBJECTIVE: To describe the characteristics and the evolution of patients with solid tumours admitted to the ICU and to identify factors associated with hospital mortality and to evaluate three illness severity scores. MATERIAL AND METHODS: Descriptive study including 132 patients with solid tumour admitted to the ICU (2010-2016). Demographics and cancer-related data, organ failures, life-supporting therapies and severity scores: APACHE II, SOFA and ICU Cancer Mortality Model (ICMM) were collected. RESULTS: There were 58 patients admitted for medical reasons and 74 for scheduled surgery. The ICU and hospital mortality rate were 12.9% and 19.7%, respectively. The medical reason for admission, the number of organ failures, and the need of life-supporting therapies were significantly associated with a higher mortality (p<0.05). In the logistic regression analysis, the three severity scores: SOFA (OR 1.18, 95% IC 1.14-1.48), APACHE II (OR 1.11, 95% CI 1.09-1.27), and ICMM (OR 1.03, 95% CI 1.02-1.07) were independently associated with a higher mortality (p<0.05). To evaluate the discrimination, the area under the receiver operating characteristics curves (AUROC) were calculated: APACHE II (0.795, 95% CI 0.69-0.9), SOFA (0.77, 95% CI 0.69-0.864) and ICMM (0.794, 95% CI 0.697-0.891). The comparison of AUC ROC after DeLong's test showed no difference between them. CONCLUSION: Hospital mortality was associated with the type and severity of acute illness. The three severity scores were useful to assess outcome and accurate in the discrimination, but we did not find a significant difference between them.
Filiaciones:
Pérez Pérez ML:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
:
Servicio de Oncología Médica, Hospital General Universitario de Elda, Alicante, Spain
Balandín Moreno B:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Maximiano Alonso C:
Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Palacios Castañeda D:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Ferreres Franco J:
Servicio de Medicina Intensiva, Hospital Clínico de Valencia, Valencia, Spain
García Sanz J:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Villanueva Fernández H:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Valdivia de la Fuente M:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Ortega López A:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Alcántara Carmona S:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Pérez Redondo M:
Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Royuela Vicente A:
Unidad de Bioestadística, Instituto de Investigación Sanitaria Puerta de Hierro Majadahonda, Madrid, Spain
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