Early childhood growth is associated with lung function at 7 years: a prospective population-based study
Por:
Peralta GP, Abellan A, Montazeri P, Basterrechea M, Esplugues A, González-Palacios S, Roda C, Santa-Marina L, Sunyer J, Vrijheid M, Casas M and Garcia-Aymerich J
Publicada:
1 dic 2020
Ahead of Print:
24 dic 2020
Resumen:
Previous studies have related early postnatal growth with later lung function but their interpretation is limited by the methods used to assess a child's growth. We aimed to assess the association of early childhood growth, measured by body mass index (BMI) trajectories up to 4 years, with lung function at 7 years.
We included 1257 children from the Spanish Infancia y Medio Ambiente population-based birth cohort. Early childhood growth was classified into five categories based on BMI trajectories up to 4 years previously identified using latent class growth analysis. These trajectories differed in birth size ("lower", "average", "higher") and in BMI gain velocity ("slower", "accelerated"). We related these trajectories to lung function (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory flow at 25%-75% of FVC (FEF25-75%)) at 7 years, using multivariable mixed regression.
Compared to children with average birth size and slower BMI gain (reference), children with higher birth size and accelerated BMI gain had a higher FVC % pred (3.3%, 95% CI 1.0%-5.6%) and a lower FEV1/FVC % pred (-1.5%, 95% CI -2.9%-0.1%) at 7 years. Similar associations were observed for children with lower birth size and accelerated BMI gain. Children with lower birth size and slower BMI gain had lower FVC % pred at 7 years. No association was found for FEF25-75%.
Independently of birth size, children with accelerated BMI gain in early childhood had higher lung function at 7 years but showed airflow limitation. Children with lower birth size and slower BMI gain in early childhood had lower lung function at 7 years.
Filiaciones:
Peralta GP:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Abellan A:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain
Montazeri P:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Basterrechea M:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Public Health Division of Gipuzkoa, Basque Government, San Sebastián, Spain
:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I, Universitat de Valencia, Valencia, Spain
Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain
González-Palacios S:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Department of Public Health, History of Medicine and Gynecology, Miguel Hernández University and Institute for Health and Biomedical Research (ISABIAL Foundation), Alicante, Spain
Roda C:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Université de Paris, CRESS, INSERM ? HERA team (Health Environmental Risk Assessment), INRA, Paris, France
Santa-Marina L:
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Public Health Division of Gipuzkoa, Basque Government, San Sebastián, Spain
Sunyer J:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Vrijheid M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Casas M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Shared last authorship
Garcia-Aymerich J:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Shared last authorship
Bronze, Green Accepted
|