Biomonitoring of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human milk: Exposure and risk assessment for lactating mothers and breastfed children from Spain
Por:
Hernández CS, Pardo O, Corpas-Burgos F, Fernández SF, López A, Coscollà C, Vento M, Yusà V and BETTERMILK
Publicada:
20 nov 2020
Ahead of Print:
9 jul 2020
Resumen:
The main objective of the present research was to evaluate the levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (dl-PCBs) in the human milk of Spanish lactating women who participated in the t:RMILK project so that exposure and risk could be assessed for these mothers and their breastfed children. The total Sigma PCDD/Fs + dl-PCBs TEQ(2005) concentrations in the upper-bound (UB) ranged from 129 to 13.48 pg-TEQ(2005) g(-1) lipid.The estimated geometric mean level for the sum of PCDD/F and dl-PCBs was 4.10 and 4.42 pg-TEQ(2005) g(-1) lipid, lower-bound (LB) and UB respectively and were below the reference level reported by EFSA, which is associated with adverse effects in boys of 9 years and related to lactating mothers' exposure values of the tolerable weekly intake (TWI) of around 2 pg-TEQ(2005) kg(-1) bw per week. Nevertheless, it was exceeded when the 95th percentile (8.31 pg-TEQ(2005) g(-1) lipid, as UB) was considered. Results from a multiple regression analysis showed that age has a significant impact on milk Sigma PCDD/Fs + dl PCBs levels, with higher concentrations observed in the milk from older mothers. (C) 2020 Elsevier B.V. All rights reserved.
Filiaciones:
:
Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Department of Analytical Chemistry, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain
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Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Department of Analytical Chemistry, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain
Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain
:
Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
:
Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Department of Analytical Chemistry, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain
:
Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
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Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Vento M:
Neonatal Research Group, Health Research Institute La Fe, Av. Abril Martorell, 106, 46026 Valencia, Spain
:
Área de Seguridad Alimentaria, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Public Health Laboratory of Valencia, Av. Catalunya, 21, 46020 Valencia, Spain
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