Asymptomatic Strongyloidiasis among Latin American Migrants in Spain: A Community-Based Approach.
Por:
Ramos-Sesma V, NAVARRO, M, Llenas-García J, Gil-Anguita C, Torrús-Tendero D, Wikman-Jorgensen P, Amador-Prous C, Ventero-Martín MP, Garijo-Sainz AM, García-López M, Pujades-Tárraga AI, Bernal-Alcaraz C, Santonja A, Guevara-Hernández P, Flores-Chávez M, Saugar JM, Ramos-Rincón JM and Corazones Sin Chagas Platform
Publicada:
24 jun 2020
Ahead of Print:
24 jun 2020
Resumen:
Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic. AIM: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain. METHODOLOGY: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany). RESULTS: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (<18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66; 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases. CONCLUSION: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients' adherence to the medical follow-up.
Filiaciones:
Ramos-Sesma V:
Internal Medicine Service, HLA Inmaculada Hospital, 18004 Granada, Spain
:
Public Health, Science History and Gynecology Department, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Alicante, Spain
:
Internal Medicine Service, Vega Baja Hospital-FISABIO, Orihuela, 03314 Alicante, Spain
Clinica Medicine Department, University Miguel Hernández de Elche, 03550 Sant Joan d'Alacant, Alicante, Spain
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Internal Medicine Service, Marina Baixa Hospital, La Vila Joiosa, 03570 Alicante, Spain
Torrús-Tendero D:
Internal Medicine Service, General University Hospital of Alicante-ISABIAL, 03550 Alicante, Spain
Department of Parasitology, Universidad Miguel Hernández de Elche, 03550 Alicante, Spain
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Internal Medicine Service, University Clinical Hospital Sant Joan d'Alacant-FISABIO, 03550 Alicante, Spain
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Internal Medicine Service, Marina Baixa Hospital, La Vila Joiosa, 03570 Alicante, Spain
Ventero-Martín MP:
Microbiology Service, General University Hospital of Alicante -ISABIAL, 03010 Alicante, Spain
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Internal Medicine Service, Marina Baixa Hospital, La Vila Joiosa, 03570 Alicante, Spain
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Internal Medicine Service, Vega Baja Hospital-FISABIO, Orihuela, 03314 Alicante, Spain
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Internal Medicine Service, Marina Baixa Hospital, La Vila Joiosa, 03570 Alicante, Spain
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Internal Medicine Service, Vega Baja Hospital-FISABIO, Orihuela, 03314 Alicante, Spain
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Internal Medicine Service, Marina Baixa Hospital, La Vila Joiosa, 03570 Alicante, Spain
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Internal Medicine Service, Vega Baja Hospital-FISABIO, Orihuela, 03314 Alicante, Spain
Flores-Chávez M:
Foundation Mundo Sano, 28046 Madrid, Spain
Parasitology Service, National Center of Microbiology, 28222 Madrid, Spain
Saugar JM:
Parasitology Service, National Center of Microbiology, 28222 Madrid, Spain
Ramos-Rincón JM:
Clinica Medicine Department, University Miguel Hernández de Elche, 03550 Sant Joan d'Alacant, Alicante, Spain
Internal Medicine Service, General University Hospital of Alicante-ISABIAL, 03550 Alicante, Spain
gold, Green Published
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