Serum Phospholipid Fatty Acids and Mammographic Density in Premenopausal Women


Por: Lope V, Del Pozo MDP, Criado-Navarro I, Pérez-Gómez B, Pastor-Barriuso R, Ruiz E, Castelló A, Lucas P, Sierra Á, Salas-Trejo D, Llobet R, Martínez I, Romieu I, Chajès V, Priego-Capote F and Pollán M

Publicada: 1 sep 2020 Ahead of Print: 25 jun 2020
Resumen:
Background: The role of fatty acids (FAs) on mammographic density (MD) is unclear, and available studies are based on self-reported dietary intake. Objectives: This study assessed the association between specific serum phospholipid fatty acids (PLFAs) and MD in premenopausal women. Methods: The cross-sectional study DDM-Madrid recruited 1392 Spanish premenopausal women, aged 39-50 y, who attended a screening in a breast radiodiagnosis unit of Madrid City Council. Women completed lifestyle questionnaires and FFQs. Percentage MD was estimated using a validated computer tool (DM-Scan), and serum PLFA percentages were measured by GC-MS. Multivariable linear regression models were used to quantify the association of FA tertiles with MD. Models were adjusted for age, education, BMI, waist circumference, parity, oral contraceptive use, previous breast biopsies, and energy intake, and they were corrected for multiple testing. Results: Women in the third tertile of SFAs showed significantly higher MD compared with those in the first tertile (beta(T3vsT1) = 7.53; 95% CI: 5.44, 9.61). Elevated relative concentrations of palmitoleic (beta(T3vsT1) = 3.12; 95% CI: 0.99, 5.25) and gondoic (beta(T3vsT1) = 2.67; 95% CI: 0.57, 4.77) MUFAs, as well as high relative concentrations of palmitelaidic (beta(T3vsT1) = 5.22; 95% CI: 3.15, 7.29) and elaidic (beta(T3vsT1) = 2.69; 95% CI: 0.59, 4.79) trans FAs, were also associated with higher MD. On the contrary, women with elevated relative concentrations of n-6 (omega-6) linoleic (beta(T3vsT1) = -5.49; 95% CI; -7.62, -3.35) and arachidonic (beta(T3vsT1) = -4.68; 95% CI: -6.79, -2.58) PUFAs showed lower MD. Regarding desaturation indices, an elevated palmitoleic to palmitic ratio and a low ratio of oleic to steric and arachidonic to dihomo. gamma-linolenic acids were associated with higher MD. Conclusions: Spanish premenopausal women with high relative concentrations of most SFAs and some MUFAs and trans FAs showed an increased MD, whereas those with high relative concentrations of some n-6 PUFAs presented lower density. These results, which should be confirmed in further studies, underscore the importance of analyzing serum FAs individually.

Filiaciones:
Lope V:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

Del Pozo MDP:
 Department of Preventive Medicine, Public Health, and Microbiology, Autonomous University of Madrid, Madrid, Spain

Criado-Navarro I:
 Department of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of Cordoba, Cordoba, Spain

 Maimónides Institute of Biomedical Research, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

Pérez-Gómez B:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

Pastor-Barriuso R:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

Ruiz E:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

Castelló A:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

 Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain

Lucas P:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

Sierra Á:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain

 Valencian Breast Cancer Screening Program, General Directorate of Public Health, Valencia, Spain

 Área de Cáncer y Salud Pública, Center for Public Health Research CSISP, FISABIO, Valencia, Spain

Llobet R:
 Institute of Computer Technology, Polytechnic University of Valencia, Valencia, Spain

:
 Valencian Breast Cancer Screening Program, General Directorate of Public Health, Valencia, Spain

 Área de Cáncer y Salud Pública, Center for Public Health Research CSISP, FISABIO, Valencia, Spain

Romieu I:
 Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico

 Huber Department of Global Health, Emory University, Atlanta, GA, USA

Chajès V:
 Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France

Priego-Capote F:
 Department of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of Cordoba, Cordoba, Spain

 Maimónides Institute of Biomedical Research, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

Pollán M:
 Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
ISSN: 15416100





JOURNAL OF NUTRITION
Editorial
American Society for Nutritional Sciences, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND, Estados Unidos America
Tipo de documento: Article
Volumen: 150 Número: 9
Páginas: 2419-2428
WOS Id: 000568434200025
ID de PubMed: 32584993
imagen Green Published, hybrid

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