Iron deficiency and safety of ferric carboxymaltose in patients with acute heart failure. AHF-ID study
Por:
Jacob J, Miró Ò, Ferre C, Borraz-Ordás C, Llopis-García G, Comabella R, Fernández-Cañadas JM, Mercado A, Roset A, Richard-Espiga F, Valero-Domènech A, Martínez-Gimeno JL, Martín-Sánchez FJ, Llorens P, Berrocal-Gil P, Pérez-Durá MJ, Álvarez-Pérez JM, López-Díez P, Herrero-Puente P and Comín-Colet J
Publicada:
1 oct 2020
Ahead of Print:
1 jun 2020
Categoría:
Medicine (miscellaneous)
Resumen:
Introduction The presence of iron deficiency (ID) in patients with acute heart failure (AHF) is high. There are few studies on the characteristics of these patients and the safety of ferric carboxymaltose administration (FCM). Objective Study the differences among patients with AHF based on the presence and type of ID as well as the safety of FCM administration in these patients. Method The AHF-ID study is a multicentre, analytical, prospective follow-up cohort including patients admitted to six Spanish hospitals for AHF. ID was defined as serum ferritin <100 mu g/L (group A) or ferritin 100-299 mu g/L with a TSAT <20% (group B). In cases receiving FCM the appearance of adverse events was analysed. Adjusted Cox regression was used to determine the association with 30-days reattendance for AHF after discharge. Results A total of 221 patients were recruited; 191 (86.4%) presented ID, 121 (63.4%) group A and 70 (36.6%) group B. There were scarce differences between the groups analysed. No differences were found in 30-days reattendance for AHF. FCM was administered to 158 (71.5%) patients, with 8 (5.1%) presenting adverse events, the most frequent being digestive alterations. Treatment was not discontinued in any case. Conclusions There are scarce differences between the presence and the type of ID in patients with AHF. The administration of FCM in patients with ID and AHF is safe.
Filiaciones:
Jacob J:
Emergency department and Short Stay Unit, Bellvitge University Hospital. L'Hospitalet de Llobregat. Barcelona, Spain
Miró Ò:
Emergency Department, Hospital Clinic, IDIBAPS, Barcelona, Spain
Medical School, University of Barcelona, Spain
Ferre C:
Emergency department and Short Stay Unit, Bellvitge University Hospital. L'Hospitalet de Llobregat. Barcelona, Spain
:
Emergency department. Hospital, Universitario Doctor Peset, Valencia, Spain
Llopis-García G:
Emergency Department, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain
Comabella R:
Emergency department and Short Stay Unit, Bellvitge University Hospital. L'Hospitalet de Llobregat. Barcelona, Spain
Fernández-Cañadas JM:
Emergency Department, Home Hospitalization and Short Stay Unit, Hospital General de Alicante, Alicante, Spain
Mercado A:
Emergency department. Hospital, Universitari i Politecnic La Fe, Valencia, Spain
Roset A:
Emergency department and Short Stay Unit, Bellvitge University Hospital. L'Hospitalet de Llobregat. Barcelona, Spain
Richard-Espiga F:
Emergency department. Hospital, Universitario de Burgos, Burgos, Spain
:
Emergency department. Hospital, Universitario Doctor Peset, Valencia, Spain
:
Emergency department. Hospital, Universitario Doctor Peset, Valencia, Spain
Martín-Sánchez FJ:
Emergency Department, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain
Llorens P:
Emergency Department, Home Hospitalization and Short Stay Unit, Hospital General de Alicante, Alicante, Spain
Berrocal-Gil P:
Internal Medicine. Hospital Universitari i Politecnic La Fe, Valencia, Spain
Pérez-Durá MJ:
Emergency department. Hospital, Universitari i Politecnic La Fe, Valencia, Spain
Álvarez-Pérez JM:
Emergency department. Hospital, Universitario de Burgos, Burgos, Spain
López-Díez P:
Emergency department. Hospital, Universitario de Burgos, Burgos, Spain
Herrero-Puente P:
Emergency Department, Hospital Universitario Central de Asturias, Oviedo, Spain
Comín-Colet J:
Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain
Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
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