Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry
Por:
Salamero, O, Mart?nez-Cuadr?n, D, Sobas, M, Benavente, C, Vives, S, De la Serna, J, P?rez-Encinas, M, Escoda, L, Gil C, Brunet, S, Ramos, F, Esteve, J, Amigo, M, Krsnik, I, Manso, F, Arias, J, Gonz?lez-Campos, J, Serrano, J, Oleksiuk, J, Barrios, M, Garc?a-Boyero, R, Novo, A, Sanz, M, Montesinos, P, Helbig, G, Holowiecka, A, Armatys, A, Hawrylecka, D, Golos, A, Ejduk, A, Majcherek, M, Skret, A, Czyzewska, J, Grosicki, S, Zarzycka, E, Watek, M, Piatkowska-Jakubas, B, Holojda, J, Pluta, A, Podhorecka, M, Gromek, T, Guzicka, E, Charlinski, G, Paluszewska, M, de Heredia, J, Hern?ndez, J, Arias, J, Ramos, F, Rom?n, A, de la Serna, J, Negri, S, Ray?n, C, Esteve, J, Fern?ndez-Calvo, F, D?az-Mediavilla, J, Gil, C, P?rez-Encinas, M, Tormo, M, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, M, Guardia, R, Manso, F, Rivas, C, Esquembre, C, Garc?a, R, Alcal?, A, L?pez, J, Rubio, V, Amigo, M, Linares, M, Ribera, J, San Miguel, J, Deb?n, G, Escoda, L, de la C?mara, R, Molines, A, Loureiro, C, Allegue, M, Amador, L, Mart?, J, Madero, L, Lassaletta, A, Cabezudo, M, Garc?a-Larana, J, Rojas, R, Ortega, F, Pe?arrubia, M, Puente, F, Lopez-Ibor, B, Brunet, S, Bergua, J, Ib??ez, J, S?nchez, P, Novo, A, Font, L, Guinea, J, Montero, A, Gonz?lez, M, Sanz, M, Mart?n, G, Mart?nez, J, Montesinos, P, Verdeguer, A, Garc?a, P, Conde, E, Garc?a, J, Capote, F, Krsnik, I, Bueno, J, Bastida, P, Rubio, A, Fuster, J, Gonz?lez, J, P?rez, I, Molina, J, Mateos, M, Ardaiz, M, Rodr?guez-Calvillo, M, Poder?s, C, Arn?n, M, Duarte, R, Hern?ndez, J, D?az-Morfa, M, Mart?n-Chac?n, E, Calvo-Villas, J, Garc?a-Belmonte, D, Hern?ndez-Maraver, D, Miskiewicz, W, PETHEMA Grp and PALG Grp
Publicada:
19 sep 2019
Resumen:
Acute promyelocytic leukemia is infrequent among patients aged >= 75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were >= 75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population.
Filiaciones:
Salamero, O:
UAB, Dept Med, Hosp Univ Vall dHebron, VHIO, Barcelona, Spain
Mart?nez-Cuadr?n, D:
Hosp Univ & Politecn La Fe, Valencia, Spain
Inst Carlos III, CIBERONC, Madrid, Spain
Sobas, M:
Wroclaw Med Univ, Dept Hematol Blood Neoplasms & Bone Marrow Transp, Wroclaw, Poland
Benavente, C:
Hosp Clin San Carlos, Madrid, Spain
Vives, S:
ICO Hosp Univ Germans Trias & Pujol, Jose Carreras Res Inst, Badalona, Spain
De la Serna, J:
Hosp 12 Octubre, Madrid, Spain
P?rez-Encinas, M:
Hosp Clin Univ, Santiago De Compostela, Spain
Escoda, L:
Hosp Joan 23, Tarragona, Spain
Gil C:
Hosp Gen Alicante, Alicante, Spain
Hosp Infantil, Hosp Clin San Carlos, Madrid, Spain
Brunet, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Ramos, F:
Hosp Univ Leon, Leon, Spain
Hosp Univ, Leon, Spain
Esteve, J:
Hosp Clin Barcelona, Barcelona, Spain
Amigo, M:
Hosp Morales Meseguer, Murcia, Spain
Hosp Gen Murcia, Murcia, Spain
Krsnik, I:
Hosp Puerta del Hierro, Madrid, Spain
Hosp Univ Puerta de Hierro, Madrid, Spain
Manso, F:
Hosp Gen Albacete, Albacete, Spain
Arias, J:
Hosp Univ Lucus Augusti, Lugo, Spain
Complexo Hosp Xeral Calde, Lugo, Spain
Gonz?lez-Campos, J:
Hosp Univ Virgen del Rocio, Seville, Spain
Serrano, J:
Hosp Reina Sofia, Cordoba, Spain
Oleksiuk, J:
Med Univ Bialystok, Bialystok, Poland
Barrios, M:
Hosp Reg Univ Carlos Haya, Malaga, Spain
:
Hosp Gen Castellon, Castellon de La Plana, Spain
Novo, A:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Hosp Son Dureta, Palma De Mallorca, Spain
Sanz, M:
Hosp Univ & Politecn La Fe, Valencia, Spain
Inst Carlos III, CIBERONC, Madrid, Spain
Montesinos, P:
Hosp Univ & Politecn La Fe, Valencia, Spain
Inst Carlos III, CIBERONC, Madrid, Spain
Hosp Univ La Fe, Valencia, Spain
Helbig, G:
Med Univ Silesia, Katowice, Poland
Holowiecka, A:
Med Univ Silesia, Katowice, Poland
Armatys, A:
Med Univ Silesia, Katowice, Poland
Hawrylecka, D:
Podkarpacie Oncol Ctr, Brzozow, Poland
Golos, A:
Inst Hematol & Blood Transfus, Warsaw, Poland
Ejduk, A:
Inst Hematol & Blood Transfus, Warsaw, Poland
Majcherek, M:
Univ Med Sci, Poznan, Poland
Skret, A:
Med Univ Rzeszow, Rzeszow, Poland
Czyzewska, J:
Med Univ Bydgoszcz, Bydgoszcz, Poland
Grosicki, S:
City Hosp Chorzow, Chorzow, Poland
Zarzycka, E:
Med Univ Sch Gdansk, Gdansk, Poland
Watek, M:
Holy Cross Canc Ctr Kielce, Kielce, Poland
Piatkowska-Jakubas, B:
Jagiellonian Univ, Coll Med, Krakow, Poland
Holojda, J:
City Hosp Legnica, Legnica, Poland
Pluta, A:
Med Univ Lodz, Lodz, Poland
Podhorecka, M:
Med Univ Lublin, Lublin, Poland
Gromek, T:
Med Univ Lublin, Lublin, Poland
Guzicka, E:
Med Univ Szczecin, Szczecin, Poland
Charlinski, G:
Nicolaus Copernicus Hosp Torun, Torun, Poland
Paluszewska, M:
Med Univ Warsaw, Warsaw, Poland
de Heredia, J:
Basurtuko Ospitalea, Bilbao, Spain
Hern?ndez, J:
Complejo Hosp Segovia, Segovia, Spain
Arias, J:
Hosp Univ Lucus Augusti, Lugo, Spain
Complexo Hosp Xeral Calde, Lugo, Spain
Ramos, F:
Hosp Univ Leon, Leon, Spain
Hosp Univ, Leon, Spain
Rom?n, A:
Fdn Jimenez Diaz, Madrid, Spain
de la Serna, J:
Hosp 12 Octubre, Madrid, Spain
Negri, S:
Hosp Carlos Haya, Malaga, Spain
Ray?n, C:
Hosp Cent Asturias, Oviedo, Spain
Esteve, J:
Hosp Clin Barcelona, Barcelona, Spain
Fern?ndez-Calvo, F:
Hosp Clin Valladolid, Valladolid, Spain
D?az-Mediavilla, J:
Hosp Clin San Carlos, Madrid, Spain
Gil, C:
Hosp Gen Alicante, Alicante, Spain
Hosp Infantil, Hosp Clin San Carlos, Madrid, Spain
P?rez-Encinas, M:
Hosp Clin Univ, Santiago De Compostela, Spain
Tormo, M:
Hosp Clin Univ, Valencia, Spain
Olave, M:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Amutio, E:
Hosp Cruces, Baracaldo, Spain
Pedro, C:
Hosp del Mar, Barcelona, Spain
Gorosquieta, A:
Hosp Navarra, Pamplona, Spain
Viguria, M:
Hosp Navarra, Pamplona, Spain
Zudaire, M:
Hosp Navarra, Pamplona, Spain
Molero, T:
Hosp Dr Negrin, Las Palmas Gran Canaria, Spain
:
Hosp Dr Peset, Valencia, Spain
Guardia, R:
Hosp Dr Trueta, Girona, Spain
Manso, F:
Hosp Gen Albacete, Albacete, Spain
Rivas, C:
Hosp Gen Alicante, Alicante, Spain
Esquembre, C:
Hosp Gen Alicante, Oncol Pediat, Alicante, Spain
Garc?a, R:
Hosp Gen Castellon, Castellon de La Plana, Spain
Alcal?, A:
Hosp 12 Octubre, Madrid, Spain
Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain
L?pez, J:
Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain
Rubio, V:
Hosp Gen Jerez de la Frontera, Cadiz, Spain
Amigo, M:
Hosp Gen Murcia, Murcia, Spain
Linares, M:
Hosp Gen Valencia, Valencia, Spain
Ribera, J:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
San Miguel, J:
Hosp Insular Las Palmas, Las Palmas Gran Canaria, Spain
Deb?n, G:
Hosp Juan Canalejo, La Coruna, Spain
Escoda, L:
Hosp Joan 23, Tarragona, Spain
de la C?mara, R:
Hosp La Princesa, Madrid, Spain
Molines, A:
Hosp Maternoinfantil Las Palmas, Las Palmas Gran Canaria, Spain
Loureiro, C:
Hosp Meixoeiro, Vigo, Spain
Allegue, M:
Hosp Montecelo, Pontevedra, Spain
Mart?, J:
Hosp Mutua Terrasa, Terrassa, Spain
Madero, L:
Hosp Nino Jesus, Madrid, Spain
Lassaletta, A:
Hosp Nino Jesus, Madrid, Spain
Cabezudo, M:
Hosp Ntra Sra Sonsoles, Avila, Spain
Garc?a-Larana, J:
Hosp Ramon & Cajal, Madrid, Spain
Rojas, R:
Hosp Reina Sofia, Cordoba, Spain
Ortega, F:
Hosp Rio Carrion, Palencia, Spain
Pe?arrubia, M:
Hosp Rio Hortega, Valladolid, Spain
Puente, F:
Hosp San Jorge, Huesca, Spain
Lopez-Ibor, B:
Hosp San Rafael, Madrid, Spain
Brunet, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Bergua, J:
Hosp San Pedro Alcantara, Caceres, Spain
Ib??ez, J:
Hosp Santa Maria del Rosell, Cartagena, Colombia
S?nchez, P:
Hosp Severo Ochoa, Leganes, Spain
Novo, A:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Hosp Son Dureta, Palma De Mallorca, Spain
Font, L:
Hosp Tortosa, Tarragona, Spain
Guinea, J:
Hosp Txagorritxu, Vitoria, Spain
Montero, A:
Hosp Univ Aire, Madrid, Spain
Gonz?lez, M:
Hosp Univ Salamanca, Salamanca, Spain
Sanz, M:
Hosp Univ La Fe, Valencia, Spain
Mart?n, G:
Hosp Univ La Fe, Valencia, Spain
Mart?nez, J:
Hosp Univ La Fe, Valencia, Spain
Montesinos, P:
Hosp Univ & Politecn La Fe, Valencia, Spain
Inst Carlos III, CIBERONC, Madrid, Spain
Hosp Univ La Fe, Valencia, Spain
Verdeguer, A:
Hosp Univ La Fe, Hosp Infantil, Valencia, Spain
Garc?a, P:
Hosp Univ La Paz, Hosp Infantil, Madrid, Spain
Conde, E:
Hosp Univ Marques de Valdecilla, Santander, Spain
Garc?a, J:
Hosp Univ Principe Asturias, Alcala De Henares, Spain
Capote, F:
Hosp Univ Puerta del Mar, Cadiz, Spain
Krsnik, I:
Hosp Puerta del Hierro, Madrid, Spain
Hosp Univ Puerta de Hierro, Madrid, Spain
Bueno, J:
Hosp Univ Vall dHebron, Barcelona, Spain
Bastida, P:
Hosp Univ Maternoinfantil Vall DHebron, Barcelona, Spain
Rubio, A:
Hosp Univ Virgen de la Arrixaca, Murcia, Spain
Fuster, J:
Hosp Univ Virgen de la Arrixaca, Pediat, Murcia, Spain
Gonz?lez, J:
Hosp Univ Virgen del Rocio, Seville, Spain
P?rez, I:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Molina, J:
Hosp Virgen del Camino, Infantil, Pamplona, Spain
Mateos, M:
Hosp Virgen del Camino, Adultos, Pamplona, Spain
Ardaiz, M:
Hosp Virgen del Camino, Adultos, Pamplona, Spain
Rodr?guez-Calvillo, M:
Clin San Miguel, Pamplona, Spain
Poder?s, C:
Hosp Xeral Cies, Vigo, Spain
Arn?n, M:
Inst Catala Oncol, Lhospitalet De Llobregat, Spain
Duarte, R:
Inst Catala Oncol, Lhospitalet De Llobregat, Spain
Hern?ndez, J:
Hosp Fuenlabrada, Fuenlabrada, Spain
D?az-Morfa, M:
Hosp Gen Guadalajara, Guadalajara, Jalisco, Mexico
Mart?n-Chac?n, E:
Hosp Juan Ramon Jimenez, Huelva, Spain
Calvo-Villas, J:
Hosp Doctor Jose Molina Orosa, Lanzarote, Spain
Garc?a-Belmonte, D:
Hosp Madrid Norte Sanchinarro, Madrid, Spain
Hern?ndez-Maraver, D:
Hosp Univ La Paz, Madrid, Spain
Miskiewicz, W:
Wroclaw Med Univ, Wroclaw, Poland
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