Bronchial Infection and Temporal Evolution of Bronchiectasis in Patients With Chronic Obstructive Pulmonary Disease
Por:
Martinez-Garcia MA, de la Rosa-Carrillo D, Soler-Cataluña JJ, Catalan-Serra P, Ballester M, Roca Vanaclocha Y, Agramunt M, Ballestin J, Garcia-Ortega A, Oscullo G, Navarro-Soriano C and Agusti A
Publicada:
1 feb 2021
Ahead of Print:
22 ene 2020
Resumen:
Background. Bronchiectasis (BE) impact the clinical course and prognosis of patients with chronic obstructive pulmonary disease (COPD). Yet, the temporal evolution of BE in these patients is unknown. This study seeks to assess the temporal evolution of BE in persons with COPD.
Methods. 201 moderate-to-severe patients were recruited between 2004 and 2007 and followed up at least every 6 monts (median of 102 months). To investigate the temporal evolution of BE, in 2015 a second high-resolution computed tomography scan (HRCT) was obtained in survivors and compared with the one obtained at recruitment.
Results. 99 (49.3%) died during follow-up. The second HRCT could be obtained in 77 patients and showed that (1) in 27.3% of patients BE never developed, in 36.4% they remained stable, in 16.9% they increased in size and/or extension, and in 19.5% new BE emerged; and that (2) the presence of chronic purulent sputum (hazard ratio [HR], 2.8 [95% confidence interval (CI), 1.3-5.8]), number of hospitalizations due to exacerbatons (HR, 1.2 [95% CI, 1.1-1.5]), and number of pathogenic microorganism (PPM) isolations (HR, 1.1 [95% CI, 1.02-1.3]) were independent risk factors for the progression or development of BE.
Conclusions. The presence of chronic purulent sputum production, number of PPMs isolated in sputum, and number of hospitalizations due to exacerbations of COPD are independent risk factors of BE progression in patients with COPD.
Filiaciones:
Martinez-Garcia MA:
Respiratory Department. Hospital Universitario y Politécnico La Fe. Valencia, Spain
de la Rosa-Carrillo D:
Respiratory Unit. Hospital Platón. Barcelona, Spain
:
Respiratory Department. Hospital Arnau de Vilanova. Valencia Spain
:
Respiratory Department. Hospital Arnau de Vilanova. Valencia Spain
:
Pneumology Unit. Hospital General de Requena Spain
Roca Vanaclocha Y:
Radiology Department. Hospital Plató. Barcelona Spain
:
Radiology Unit. Hospital General de Requena. Valencia Spain
:
Radiology Department. Hospital Arnau de Vilanova. Valencia Spain
Garcia-Ortega A:
Respiratory Department. Hospital Universitario y Politécnico La Fe. Valencia, Spain
Oscullo G:
Respiratory Department. Hospital Universitario y Politécnico La Fe. Valencia, Spain
Navarro-Soriano C:
Respiratory Department. Hospital Universitario y Politécnico La Fe. Valencia, Spain
Agusti A:
Respiratory Institute, Hospital Clinic, Univ. Barcelona, IDIBAPS, CIBER Enfermedades Respiratorias, Spain
Open Access
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