Tuberculosis Treatment Outcomes Among Children in Rural Southern Mozambique A 12-year Retrospective Study
Por:
Moon, T, Nacarapa, E, Verdu, M, Macuacua, S, Mugabe, D, Gong, W, Carlucci, J, Ramos J and Valverde, E
Publicada:
1 oct 2019
Resumen:
Background: Globally, tuberculosis (TB) remains a serious cause of morbidity and mortality for children. Mozambique is 1 of 30 high TB and TB/HIV burden countries. This study aimed to assess treatment outcomes of childhood TB in Chokwe District, Mozambique. Methods: A retrospective cohort study of children Results: Nine hundred thirty-three cases of childhood TB were enrolled, 45.9% of which were female and 49.6% were <5-years-old. Five hundred sixty-five (62%) children were HIV positive. Seven hundred sixty-two (83.6%) cases had a favorable TB treatment outcome. In comparison to children 0-4 years, the 5-14 age group had a higher odds of a favorable outcome [odds ratio: 2.02, 95% confidence interval: 1.42-3.05]. Being 5-14 years was associated with lower risk of death (hazard ratio: 0.435; 95% confidence interval: 0.299-0.632). Those starting anti-TB treatment <= 3 months after antiretroviral therapy initiation had a survival probability of approximately 75% at 1 year compared with 95% for those who were HIV negative. Conclusions: Most children in this cohort had favorable TB treatment outcomes. Worse outcomes were observed for younger children and if anti-TB treatment started <= 3 months after initiation of antiretroviral therapy. Rigorous screening for TB and isoniazid preventative therapy may reduce the burden of TB in this population and lead to better outcomes.
Filiaciones:
Moon, T:
Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Infect Dis, Nashville, TN 37232 USA
Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, 2525 West End Ave, Nashville, TN 37235 USA
Nacarapa, E:
Carmelo Hosp Chokwe, Daughters Char, St Vincent Paul, Div Infect Dis, Chokwe, Gaza Province, Mozambique
Vincentian Assoc Fight AIDS & TB, Tinpswalo Assoc, Res Unit, Chokwe, Gaza Province, Mozambique
Verdu, M:
Carmelo Hosp Chokwe, Daughters Char, St Vincent Paul, Div Infect Dis, Chokwe, Gaza Province, Mozambique
Macuacua, S:
Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, 2525 West End Ave, Nashville, TN 37235 USA
Ctr Hlth Res Manhica CISM, Manhica, Mozambique
Mugabe, D:
Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, 2525 West End Ave, Nashville, TN 37235 USA
Gong, W:
Vanderbilt Univ, Dept Biostat, Med Ctr, Nashville, TN USA
Carlucci, J:
Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Infect Dis, Nashville, TN 37232 USA
Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, 2525 West End Ave, Nashville, TN 37235 USA
Ramos J:
Univ Gen Hosp Alicante, Dept Internal Med, Alicante, Spain
Miguel Hernandez Univ Elche, Elche, Spain
Valverde, E:
Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, 2525 West End Ave, Nashville, TN 37235 USA
Aurum Inst, Maputo, Mozambique
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