The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study.
Por:
Castillejo A, Mata-Balaguer T, Montenegro P, Ochoa E, Lázaro R, Martínez A, Castillejo M, Guarinos C, Barbera V, Guillén-Ponce C, Carrato A and Soto J
Publicada:
18 jun 2009
Resumen:
TGF-beta receptor type I is a mediator of growth inhibitory signals. TGFBR1*6A (rs11466445) is a common polymorphic variant of the TGF-beta receptor I gene and has been associated with tumour susceptibility. Nevertheless, the role of this polymorphism as a risk factor for colorectal cancer is controversial. The aim of this study was to assess the association between TGFBR1*6A and colorectal cancer, age, sex, tumour location and tumour stage in a Spanish population.
Filiaciones:
Castillejo A:
Molecular Oncology Group, Elche University Hospital, Camino Almazara 11, Elche, Spain.
Open Access
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