Incidence of pertussis in persons = 15 years of age in Valencia, Spain:: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults
Por:
Diez-Domingo, J, Ballester, A, Baldo, J, Planelles, M, Villarroya, J, Alvarez, T, Peidro, M, Calero, P, Garces, M, Sorribes, I, Graullera, M, Jubert, A, San-Martin, M and Gonzalez, A
Publicada:
1 oct 2004
Resumen:
Purpose. To determine the incidence of pertussis in persons less than or equal to15 years in age in Valencia, Spain. To assess the prevalence of IgG antibodies to pertussis toxin (PT) in children, adolescents and adults.
Methods. Prospective study conducted at paediatric primary care centres. All persons less than or equal to15 years in age presented with persistent cough were enrolled. Parents completed a brief questionnaire and immunization history was obtained from paediatrician records. A blood sample was obtained, for determination of IgG antibodies to Bordetella pertussis toxin (PT) by an ELISA method. A study confirmed-case was the presence of two conditions: (1) cough illness of greater than or equal to14 days duration; and (2) ELISA absorbance value of IgG to PT greater than or equal to2. Two subjects per clinical-case (same Centre and range of age) and parents were asked to participate in the prevalence study.
Results. Sixty-one children less than or equal to15 years in age presented with symptoms leading to a clinical diagnosis of pertussis were detected. Serological evidence of recent pertussis was found in five of these patients (incidence of 46.0/100 000 persons less than or equal to15 years in age). Prevalence of antiobodies to B. pertussis (greater than or equal to0.3) in children less than or equal to15 years in age and adults was 39 and 33%, respectively. Only a minority of children, adolescents and adults had absorbance values indicative of immunity (greater than or equal to1).
Conclusions. These incidence and seroprevalence results show that despite high immunization rates in infancy, B. pertussis is circulating in Spain. (C) 2004 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
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