Seroprevalence of Varicella Among Children and Adolescents in Valencia, Spain


Por: Diez-Domingo, J, Gil, A, San-Martin, M, Gonzalez, A, Esteban, J, Baldo, J, Planelles, M, Ubeda, M, Graullera, M, Peris, A, Martinez, M, Anton, V, Gallego, D, Alvarez, T, Villarroya, J, Jubert, A, Casani, C, Peidro, C, Garcia, M and Ballester, A

Fecha de Publicación: 01/09/2005
Resumen:
This study assessed the seroprevalence of varicella antibodies in children and adolescents in Spain and evaluated the reliability of two methods for detecting susceptible individuals: (1) parental-reported history of varicella and (2) medically-documented histories maintained by the pediatrician. A total of 186 children (6 to 15 years of age) were recruited in 13 pediatric offices of Valencia, Spain. A brief case report form was completed including previous history of varicella referred by the parents, and a 5 mL blood sample was obtained. The pediatrician medical file was reviewed for antecedent of varicella. The overall prevalence of varicella antibodies was 84% and 88% in the 6-9 years and 10-15 years age brackets, respectively. The predictive value of a negative history of varicella disease was 48% by parental recall (52% "false negative"), and only 26% by medical record (74% "false negative"). However, the positive predictive value of a positive parental reported history or a positive medically-documented history was 95%. The most effective strategy for varicella vaccination of older children and adolescents in Spain will be to immunize those individuals with a lack of positive (unknown or negative) history of disease.

Direcciones
Diez-Domingo, J: VIVA, Ctr Salud, Valencia, Spain
Gil, A: Rey Juan Carlos Univ, Dept Hlth Sci, Madrid, Spain
San-Martin, M: Sanofi Pasteur MSD, Dept Med, Madrid, Spain
Gonzalez, A: Sanofi Pasteur MSD, Dept Med, Madrid, Spain
Esteban, J: Rey Juan Carlos Univ, Dept Hlth Sci, Madrid, Spain
Baldo, JM: VIVA, Ctr Salud, Valencia, Spain
Planelles, MV: VIVA, Ctr Salud, Valencia, Spain
Ubeda, MI: VIVA, Ctr Salud, Valencia, Spain
Graullera, M: VIVA, Ctr Salud, Valencia, Spain
Peris, A: VIVA, Ctr Salud, Valencia, Spain
Martinez, M: VIVA, Ctr Salud, Valencia, Spain
Anton, V: VIVA, Ctr Salud, Valencia, Spain
Gallego, D: VIVA, Ctr Salud, Valencia, Spain
Alvarez, T: VIVA, Ctr Salud, Valencia, Spain
Villarroya, JV: VIVA, Ctr Salud, Valencia, Spain
Jubert, A: VIVA, Ctr Salud, Valencia, Spain
Casani, C: VIVA, Ctr Salud, Valencia, Spain
Peidro, C: VIVA, Ctr Salud, Valencia, Spain
Garcia, M: VIVA, Ctr Salud, Valencia, Spain
Ballester, A: VIVA, Ctr Salud, Valencia, Spain
ISSN: 15548619





HUMAN VACCINES
Editorial
Landes Bioscience, 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 1 Número: 5
Páginas: 204-206s
WOS: 000208111200006
ID de PubMed: 17012857

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