Immunogenicity of a combination vaccine containing diphtheria toxoid, tetanus toxoid, three-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b when given concomitantly with 13-valent pneumococcal conjugate vaccine


Por: Gimenez-Sanchez, F, Kieninger, D, Kueper, K, Martinon-Torres, F, Bernaola, E, Diez-Domingo, J, Steul, K, Juergens, C, Gurtman, A, Giardina, P, Liang, J, Gruber, W, Emini, E, Scott, D, 501 Study Grp and 006 Study Grp

Fecha de Publicación: 11/08/2011
Resumen:
Two randomized trials of 13-valent pneumococcal conjugate vaccine (PCV13) relative to PCV7 evaluated the immune responses of coadministered antigens comprising Infanrix (R) hexa/Infanrixe (R)-IPV + Hib (diphtheria, tetanus, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Haemophilus influenzae type b). After the 3-dose infant series, immunogenic noninferiority was demonstrated for all concomitantly administered antigens between the PCV13 and PCV7 groups. All antigens elicited good booster responses after the toddler dose except pertussis toxoid; however, 99.6% subjects achieved pertussis toxoid protective antibody level >= 5 EU/mL in both groups. These results support the concomitant administration of PCV13 and Infanrix hexa/Infanrix-IPV + Hib as part of routine immunization schedules. (C) 2011 Elsevier Ltd. All rights reserved.

Direcciones
Gimenez-Sanchez, F: Hosp Torrecardenas, Dept Pediat, Almeria, Spain
Kieninger, DM: Johannes Gutenberg Univ Mainz KOR, Univ Med, Zentrum Kinder & Jugendmed, Mainz, Germany
Kueper, K: Johannes Gutenberg Univ Mainz KOR, Univ Med, Zentrum Kinder & Jugendmed, Mainz, Germany
Martinon-Torres, F: Univ Santiago de Compostela, Hosp Clin, Santiago De Compostela, Spain; Inst Invest Sanitaria Santiago, Vaccine Res Unit, Santiago, Spain
Bernaola, E: Hosp Virgen Camino Pamplona, Pamplona, Spain
Diez-Domingo, J: CSISP, Valencia, Spain
Steul, K: Johannes Gutenberg Univ Mainz KOR, Univ Med, Zentrum Kinder & Jugendmed, Mainz, Germany
Juergens, C: Pfizer Inc, Berlin, Germany
Gurtman, A: Pfizer Inc, Pearl River, NY USA
Giardina, P: Pfizer Inc, Pearl River, NY USA
Liang, JZ: Pfizer Inc, Collegeville, PA USA
Gruber, WC: Pfizer Inc, Pearl River, NY USA
Emini, EA: Pfizer Inc, Pearl River, NY USA
Scott, DA: Pfizer Inc, Pearl River, NY USA
ISSN: 13588745





Vaccine
Editorial
Elsevier BV, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, Países Bajos
Tipo de documento: Article
Volumen: 29 Número: 35
Páginas: 6042-6048s
WOS: 000294145900028
ID de PubMed: 21704105

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