Epidemiology and cost of herpes zoster and postherpetic neuralgia among patients treated in primary care centres in the valencian community of Spain


Por: Cebrian-Cuenca, A, Diez-Domingo, J, San-Martin-Rodriguez, M, Puig-Barbera, J, Navarro-Perez, J and Herpes Zoster Res Grp Valencian

Fecha de Publicación: 01/11/2011
Categoría: Infectious Diseases

Resumen:
Background: Data on the epidemiology and costs related to herpes zoster (HZ) and postherpetic neuralgia (PHN) in Spain are scarce; therefore, studies are needed to evaluate the epidemiological and economic impact of HZ and its most common complication, PHN. The present study aimed to estimate the clinical and economic burden of HZ and PHN in Valencia (Spain). Methods: We prospectively analyzed the burden of HZ and PHN and their attributable costs in patients from 25 general practices in the Autonomous Community of Valencia serving 36,030 persons aged > 14 years. All patients with a clinical diagnosis of HZ who attended these centers between December 1(st) 2006 and November 30(th) 2007 were asked to participate. Patients included were followed for 1 year. Results: Of the 130 cases of HZ followed up, continued pain was experienced by 47.6% (95% confidence interval (CI) = 35.6-56.7%) at 1 month after rash onset, by 14.5% (95% CI = 7.8-1.2%) at 3 months, by 9.0% (95% CI = 3.7-14.3%) at 6 months, and by 5.9% (95% CI = 1.5-10.3%) at 12 months. The percentage of patients with PHN increased with age, from 21.4% (95% CI = 8.3-40) in patients < 50 years to 59.2% (95% CI = 44.4- 74) in patients = 70 years. The estimated total cost for the 130 HZ cases during the follow-up period was (sic)49,160 ($67,349). Mean cost per patient was (sic)378 (range 53- 2,830) ($517, range 73-3,877). Conclusions: This study shows that PHN is a relatively common complication of HZ and that both conditions combined give rise to a significant clinical and economic burden for patients and providers.

Direcciones
Cebrian-Cuenca, AM: Ctr Salud Ayora, Valencia, Spain
Diez-Domingo, J: Ctr Super Invest Salud Publ Valencia CSISP, Valencia 46020, Spain
San-Martin-Rodriguez, M: Dept Med Sanofi Pasteur MSD, Madrid, Spain
Puig-Barbera, J: Ctr Super Invest Salud Publ Valencia CSISP, Valencia 46020, Spain
Navarro-Perez, J: CIBER Epidemiol & Publ Hlth CIBERESP, Valencia 46022, Spain
ISSN: 14712334





BMC INFECTIOUS DISEASES
Editorial
BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 11 Número:
Páginas: -s
WOS: 000298052900001
ID de PubMed: 22044665

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