Correlation of zinc with oxidative stress biomarkers.


Por: Morales-Suárez-Varela M, Llopis-González A, González-Albert V, López-Izquierdo R, González-Manzano I, Cháves J, Huerta-Biosca V and Martin-Escudero JC

Fecha de Publicación: 12/03/2015
Resumen:
Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual's physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20-59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson's C=0.639; p=0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR=2.80 (95%CI=1.09-7.18) and AOR=3.06 (95%CI=0.96-9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension.

Direcciones
Morales-Suárez-Varela M: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain. maria.m.morales@uv.es; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. maria.m.morales@uv.es; Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain. maria.m.morales@uv.es
Llopis-González A: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain. agustin.llopis@uv.es; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. agustin.llopis@uv.es; Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain. agustin.llopis@uv.es
González-Albert V: Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain. veronica.gonzalez@uv.es
López-Izquierdo R: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain. rulo636@yahoo.es
González-Manzano I: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain. isabelgonzlez@gmail.com
Cháves J: Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain. felipe.chaves@uv.es; CIBER de Diabetes y Enfermedades Metabólicas Asociados (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. felipe.chaves@uv.es
Huerta-Biosca V: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain. vicente.huerta@uv.es
Martin-Escudero JC: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain. juancarlos.martinescudero@gmail.com
ISSN: 16617827





INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Editorial
MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 12 Número: 3
Páginas: 3060-3076s
WOS: 000351929700049
ID de PubMed: 25774936

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